The Library
High-frequency oscillation for acute respiratory distress syndrome
Tools
Young, Duncan, Lamb, S. E. (Sallie E.), Shah, Sanjoy, MacKenzie, Iain, Tunnicliffe, William, Lall, Ranjit, Rowan, Kathy and Cuthbertson, Brian H. (2013) High-frequency oscillation for acute respiratory distress syndrome. New England Journal Of Medicine , Volume 368 (Number 9). pp. 806-813. doi:10.1056/NEJMoa1215716 ISSN 0028-4793.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1056/NEJMoa1215716
Abstract
Background: Patients with the acute respiratory distress syndrome (ARDS) require mechanical ventilation to maintain arterial oxygenation, but this treatment may produce secondary lung injury. High-frequency oscillatory ventilation (HFOV) may reduce this secondary damage.
Full Text of Background...
Methods:
In a multicenter study, we randomly assigned adults requiring mechanical ventilation for ARDS to undergo either HFOV with a Novalung R100 ventilator (Metran) or usual ventilatory care. All the patients had a ratio of the partial pressure of arterial oxygen (PaO2) to the fraction of inspired oxygen (FiO2) of 200 mm Hg (26.7 kPa) or less and an expected duration of ventilation of at least 2 days. The primary outcome was all-cause mortality 30 days after randomization.
Full Text of Methods...
Results:
There was no significant between-group difference in the primary outcome, which occurred in 166 of 398 patients (41.7%) in the HFOV group and 163 of 397 patients (41.1%) in the conventional-ventilation group (P=0.85 by the chi-square test). After adjustment for study center, sex, score on the Acute Physiology and Chronic Health Evaluation (APACHE) II, and the initial PaO2:FiO2 ratio, the odds ratio for survival in the conventional-ventilation group was 1.03 (95% confidence interval, 0.75 to 1.40; P=0.87 by logistic regression).
Full Text of Results...
Conclusions:
The use of HFOV had no significant effect on 30-day mortality in patients undergoing mechanical ventilation for ARDS. (Funded by the National Institute for Health Research Health Technology Assessment Programme; OSCAR Current Controlled Trials number, ISRCTN10416500.)
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||
Journal or Publication Title: | New England Journal Of Medicine | ||||
Publisher: | Massachusetts Medical Society | ||||
ISSN: | 0028-4793 | ||||
Official Date: | 28 February 2013 | ||||
Dates: |
|
||||
Volume: | Volume 368 | ||||
Number: | Number 9 | ||||
Page Range: | pp. 806-813 | ||||
DOI: | 10.1056/NEJMoa1215716 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |