Bearup, Daniel J., Evans, Neil D. and Chappell, M. J. (Michael J.) (2013) The input–output relationship approach to structural identifiability analysis. Computer Methods and Programs in Biomedicine, Volume 109 (Number 2). pp. 171-181. doi:10.1016/j.cmpb.2012.10.012 ISSN 0169-2607.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Abstract
Analysis of the identifiability of a given model system is an essential prerequisite to the determination of model parameters from physical data. However, the tools available for the analysis of non-linear systems can be limited both in applicability and by computational intractability for any but the simplest of models. The input–output relation of a model summarises the input–output structure of the whole system and as such provides the potential for an alternative approach to this analysis. However for this approach to be valid it is necessary to determine whether the monomials of a differential polynomial are linearly independent. A simple test for this property is presented in this work. The derivation and analysis of this relation can be implemented symbolically within Maple. These techniques are applied to analyse classical models from biomedical systems modelling and those of enzyme catalysed reaction schemes.
| Item Type: | Journal Article |
|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering |
| Journal or Publication Title: | Computer Methods and Programs in Biomedicine |
| Publisher: | Elsevier Ireland Ltd. |
| ISSN: | 0169-2607 |
| Official Date: | February 2013 |
| Dates: | Date Event February 2013 Published |
| Volume: | Volume 109 |
| Number: | Number 2 |
| Page Range: | pp. 171-181 |
| DOI: | 10.1016/j.cmpb.2012.10.012 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | https://wrap.warwick.ac.uk/55600/ |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |