Coleshill, Anita (1998) Synthesis of polyester dendrimers. PhD thesis, University of Warwick.

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Abstract

Dendrimers
are a fairly
new class of macromolecule.
They have many potential
uses including
use
in
surface coatings and as
host
molecules.
There
are
two
main methods available
for
constructing
dendrimers,
the convergent approach
and
the divergent
approach.
In this thesis dendrimers
were synthesised using
the
divergent
approach.
In
chapter one our original aim was to synthesise
dendrimers based on
bicine, but there were complications
involved in
synthesis
and storage of the monomer.
However, it
was possible
to
make a
iminium
salt
using
bicine
as the starting material, which was reacted with various
nucleophiles.
With 2,2-bishydroxymethylpropionic
acid
it
was possible
to
produce a generation one protected dendrimer, but deprotection could not
be
achieved.

In the third
chapter
the syntheses of
dendrimers based
on
4,4-bis(4-
hydroxyphenyl)valeric
acid are
described. Dendrimers
were successfully
synthesised up to
and
including
generation two. These
were made using various
esterification methods.
Chapter four describes the synthesis of
functionalised dendrimers. Generation
one
deprotected dendrimers
were reacted with a variety of reagents to
produce
pent-4-enoyl, urethane and lineoyl functionalised dendrimers.

Chapter five describes the analysis of
dendrimers
using
MALDI-MS. For
every
dendrimer
synthesis molecular weights were obtained well within
the
boundaries of experimental error.
It
was also shown
how
preparation time
and
laser power can affect the spectra obtained.

Item Type:	Thesis (PhD)
Subjects:	Q Science > QD Chemistry
Library of Congress Subject Headings (LCSH):	Dendrimers , Macromolecules , Polymerization, Polyesters
Official Date:	September 1998
Dates:	Date Event September 1998 Submitted
Institution:	University of Warwick
Theses Department:	Department of Chemistry
Thesis Type:	PhD
Publication Status:	Unpublished
Supervisor(s)/Advisor:	Taylor, Paul C. (Paul Christopher), Haddleton, David M., Yeates, Stephen G.
Sponsors:	University of Warwick ; Zeneca Resins
Extent:	xiii, 168 leaves
Language:	eng

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