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An atypical RNA polymerase involved in RNA silencing shares small subunits with RNA polymerase II
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Huang, Linfeng, Jones, Alexandra M., Searle, Iain, Patel, Kanu, Vogler, Hannes, Hubner, Nina C and Baulcombe, David C (2009) An atypical RNA polymerase involved in RNA silencing shares small subunits with RNA polymerase II. Nature Structural & Molecular Biology, Volume 16 (Number 1). pp. 91-93. doi:10.1038/nsmb.1539 ISSN 1545-9993.
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Official URL: http://dx.doi.org/10.1038/nsmb.1539
Abstract
Genetic evidence indicates that plant-specific homologs of DNA-dependent RNA polymerase (Pol) II large subunits form Pol IV and Pol V complexes involved in small interfering RNA production and RNA-directed DNA methylation. Here we describe evidence that Pol V contains subunits shared with Pol II, but that RNA polymerase II subunit (RPB)-4 is missing from Pol V and that RPB5 is present as a Pol V–specific isomer, RPB5b. Pol V also has other proteins that are not present in Pol II, consistent with a role of this complex as an effector of silencing.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | Nature Structural & Molecular Biology | ||||
Publisher: | Nature Publishing Group | ||||
ISSN: | 1545-9993 | ||||
Official Date: | 14 December 2009 | ||||
Dates: |
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Volume: | Volume 16 | ||||
Number: | Number 1 | ||||
Page Range: | pp. 91-93 | ||||
DOI: | 10.1038/nsmb.1539 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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