Scialdone, Antonio and Nicodemi, Mario. (2010) Statistical mechanics models for X-chromosome inactivation. Advances in Complex Systems, Vol.13 (No.3). pp. 367-376. ISSN 0219-5259

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Abstract

We present statistical mechanics models to understand the physical and molecular mechanisms of X-Chromosome Inactivation (XCI), the process whereby a female mammal cell inactivates one of its two X-chromosomes. During XCI, X-chromosomes undergo a series of complex regulatory processes. At the beginning of XCI, the X's recognize and pair, then only one X which is randomly chosen is inactivated. Afterwards, the two X's move to different positions in the cell nucleus according to their different status (active/silenced). Our models illustrate about the still mysterious physical bases underlying all these regulatory steps, i.e., X-chromosome pairing, random choice of inactive X, and "shuttling" of the X's to their post-XCI locations. Our models are based on general and robust thermodynamic roots, and their validity can go beyond XCI, to explain analogous regulatory mechanisms in a variety of cellular processes.

Item Type:	Journal Article
Subjects:	Q Science > QA Mathematics Q Science
Divisions:	Faculty of Science > Physics
Journal or Publication Title:	Advances in Complex Systems
Publisher:	World Scientific Publishing Company PTE Ltd
ISSN:	0219-5259
Date:	June 2010
Volume:	Vol.13
Number:	No.3
Number of Pages:	10
Page Range:	pp. 367-376
Identification Number:	10.1142/S0219525910002566
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/5591

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