Statistical mechanics models for X-chromosome inactivation
Scialdone, Antonio and Nicodemi, Mario. (2010) Statistical mechanics models for X-chromosome inactivation. Advances in Complex Systems, Vol.13 (No.3). pp. 367-376. ISSN 0219-5259Full text not available from this repository.
Official URL: http://dx.doi.org/10.1142/S0219525910002566
We present statistical mechanics models to understand the physical and molecular mechanisms of X-Chromosome Inactivation (XCI), the process whereby a female mammal cell inactivates one of its two X-chromosomes. During XCI, X-chromosomes undergo a series of complex regulatory processes. At the beginning of XCI, the X's recognize and pair, then only one X which is randomly chosen is inactivated. Afterwards, the two X's move to different positions in the cell nucleus according to their different status (active/silenced). Our models illustrate about the still mysterious physical bases underlying all these regulatory steps, i.e., X-chromosome pairing, random choice of inactive X, and "shuttling" of the X's to their post-XCI locations. Our models are based on general and robust thermodynamic roots, and their validity can go beyond XCI, to explain analogous regulatory mechanisms in a variety of cellular processes.
|Item Type:||Journal Article|
|Subjects:||Q Science > QA Mathematics
|Divisions:||Faculty of Science > Physics|
|Journal or Publication Title:||Advances in Complex Systems|
|Publisher:||World Scientific Publishing Company PTE Ltd|
|Number of Pages:||10|
|Page Range:||pp. 367-376|
|Access rights to Published version:||Restricted or Subscription Access|
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