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Do endobronchial valves improve outcomes in patients with emphysema?
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Barua, A., Vaughan, P., Wotton, R. and Naidu, Babu V. (2012) Do endobronchial valves improve outcomes in patients with emphysema? Interactive CardioVascular and Thoracic Surgery, Volume 15 (Number 6). pp. 1072-1076. doi:10.1093/icvts/ivs371 ISSN 1569-9293.
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Official URL: http://dx.doi.org/10.1093/icvts/ivs371
Abstract
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was whether endobronchial valves improve outcomes in patients with severe emphysema. Eighty-seven papers were found using the reported search, of which seven represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. Endobronchial Valve for Emphysema Palliation Trial demonstrated that endobronchial valve increased forced expiratory volume in one second by 4.3% (95% confidence interval 1.4–7.2) and decreased by 2.5% in the control group (95% confidence interval −5.4 to 0.4) at a 6-month interval. This benefit is more marked in patients who do not have collateral ventilation into the area of lung being isolated as mapped by bronchoscopic physiological mapping (Chartis) or by computed tomography imaging documenting intact fissures. This evidence is reflected in the Endobronchial Valve for Emphysema Palliation Trial. Patients treated with endobronchial valve with high heterogeneity and complete fissures had greater improvement in forced expiratory volume in one second at 6- and 12-month intervals. We conclude that endobronchial valve placement improves lung function, exercise capacity and quality of life in selected patients with emphysematous diseases.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | Interactive CardioVascular and Thoracic Surgery | ||||
| Publisher: | Oxford University Press | ||||
| ISSN: | 1569-9293 | ||||
| Official Date: | 2012 | ||||
| Dates: |
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| Volume: | Volume 15 | ||||
| Number: | Number 6 | ||||
| Page Range: | pp. 1072-1076 | ||||
| DOI: | 10.1093/icvts/ivs371 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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