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The activation of the CGRP receptor
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Barwell, James, Wheatley, Mark, Conner, Alex C., Taddese, Bruck, Vohra, Shabana, Reynolds, Christopher A. and Poyner, David R. (2013) The activation of the CGRP receptor. Biochemical Society Transactions, Volume 41 (Number 1). pp. 180-184. doi:10.1042/BST20120251 ISSN 0300-5127.
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Official URL: http://dx.doi.org/10.1042/BST20120251
Abstract
The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Journal or Publication Title: | Biochemical Society Transactions | ||||
Publisher: | Portland Press Ltd | ||||
ISSN: | 0300-5127 | ||||
Official Date: | February 2013 | ||||
Dates: |
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Volume: | Volume 41 | ||||
Number: | Number 1 | ||||
Page Range: | pp. 180-184 | ||||
DOI: | 10.1042/BST20120251 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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