Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Mathematical model of bursting in dissociated Purkinje neurons

Tools
- Tools
+ Tools

Forrest, Michael D. (2013) Mathematical model of bursting in dissociated Purkinje neurons. PLoS One, Volume 8 (Number 8). e68765. doi:10.1371/journal.pone.0068765 ISSN 1932-6203.

[img]
Preview
Text
WRAP_Forrest_journal.pone.0068765.pdf - Published Version
Available under License Creative Commons Attribution.

Download (837Kb) | Preview
Official URL: http://dx.doi.org/10.1371/journal.pone.0068765

Request Changes to record.

Abstract

In vitro, Purkinje cell behaviour is sometimes studied in a dissociated soma preparation in which the dendritic projection has been cleaved. A fraction of these dissociated somas spontaneously burst. The mechanism of this bursting is incompletely understood. We have constructed a biophysical Purkinje soma model, guided and constrained by experimental reports in the literature, that can replicate the somatically driven bursting pattern and which hypothesises Persistent Na+ current (INaP) to be its burst initiator and SK K+ current (ISK) to be its burst terminator.

Item Type: Journal Article
Subjects: Q Science > QA Mathematics
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science, Engineering and Medicine > Science > Computer Science
Library of Congress Subject Headings (LCSH): Purkinje cells , Purkinje cells -- Research, Neurons -- Mathematical models
Journal or Publication Title: PLoS One
Publisher: Public Library of Science
ISSN: 1932-6203
Official Date: 13 August 2013
Dates:
DateEvent
13 August 2013Published
Volume: Volume 8
Number: Number 8
Page Range: e68765
DOI: 10.1371/journal.pone.0068765
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 25 December 2015
Date of first compliant Open Access: 25 December 2015
Funder: Medical Research Council (Great Britain) (MRC)

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us