Forrest, Michael D. (2013) Mathematical model of bursting in dissociated Purkinje neurons. PLoS One, Volume 8 (Number 8). e68765. doi:10.1371/journal.pone.0068765

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Abstract

In vitro, Purkinje cell behaviour is sometimes studied in a dissociated soma preparation in which the dendritic projection has been cleaved. A fraction of these dissociated somas spontaneously burst. The mechanism of this bursting is incompletely understood. We have constructed a biophysical Purkinje soma model, guided and constrained by experimental reports in the literature, that can replicate the somatically driven bursting pattern and which hypothesises Persistent Na+ current (INaP) to be its burst initiator and SK K+ current (ISK) to be its burst terminator.

Item Type:	Journal Article
Subjects:	Q Science > QA Mathematics Q Science > QH Natural history > QH301 Biology
Divisions:	Faculty of Science > Computer Science
Library of Congress Subject Headings (LCSH):	Purkinje cells , Purkinje cells -- Research, Neurons -- Mathematical models
Journal or Publication Title:	PLoS One
Publisher:	Public Library of Science
ISSN:	1932-6203
Official Date:	13 August 2013
Dates:	Date Event 13 August 2013 Published
Date of first compliant deposit:	25 December 2015
Volume:	Volume 8
Number:	Number 8
Page Range:	e68765
DOI:	10.1371/journal.pone.0068765
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access
Funder:	Medical Research Council (Great Britain) (MRC)

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