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CHO microRNA engineering is growing up : recent successes and future challenges

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Jadhav, Vaibhav, Hackl, Matthias, Druz, Aliaksandr, Shridhar, Smriti, Chung, Cheng-Yu, Heffner, Kelley M., Kreil, David, Betenbaugh, Mike, Shiloach, Joseph, Barron, Niall, Grillari, Johannes and Borth, Nicole (2013) CHO microRNA engineering is growing up : recent successes and future challenges. Biotechnology Advances, Volume 31 (Number 8). pp. 1501-1513. doi:10.1016/j.biotechadv.2013.07.007

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Official URL: http://dx.doi.org/10.1016/j.biotechadv.2013.07.007

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Abstract

microRNAs with their ability to regulate complex pathways that control cellular behavior and phenotype have been proposed as potential targets for cell engineering in the context of optimization of biopharmaceutical production cell lines, specifically of Chinese Hamster Ovary cells. However, until recently, research was limited by a lack of genomic sequence information on this industrially important cell line. With the publication of the genomic sequence and other relevant data sets for CHO cells since 2011, the doors have been opened for an improved understanding of CHO cell physiology and for the development of the necessary tools for novel engineering strategies. In the present review we discuss both knowledge on the regulatory mechanisms of microRNAs obtained from other biological models and proof of concepts already performed on CHO cells, thus providing an outlook of potential applications of microRNA engineering in production cell lines.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
Q Science > QR Microbiology
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): RNA -- Synthesis , RNA, Genomics, Molecular genetics, Microbial genomics
Journal or Publication Title: Biotechnology Advances
Publisher: Elsevier Inc.
ISSN: 0734-9750
Official Date: 2 August 2013
Dates:
DateEvent
2 August 2013Published
Date of first compliant deposit: 25 December 2015
Volume: Volume 31
Number: Number 8
Page Range: pp. 1501-1513
DOI: 10.1016/j.biotechadv.2013.07.007
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Description:

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Funder: Austria. Bundesministerium für Wissenschaft und Forschung, National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) (NIDDKD), National Institutes of Health (U.S.) (NIH), Science Foundation Ireland (SFI), Wiener Wissenschafts, Forschungs und Technologiefonds [Vienna Science and Technology Fund] (WWTF), Baxter International Inc., Österreichisches Forschungszentrum Seibersdorf [Austrian Research Centre Seibersdorf] (ARCS), Austrian Center of Biopharmaceutical Technology (ACBT), Austrian Centre of Industrial Biotechnology (ACIB)

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