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Application of a novel tool for diagnosing bile acid diarrhoea
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Covington, James A., Westenbrink, Eric W., Ouaret, Nathalie, Harbord, Ruth, Bailey, Catherine, O'Connell, Nicola, Cullis, James, Williams, Nigel, Nwokolo, Chuka U., Bardhan, Karna Dev and Arasaradnam, Ramesh P. (2013) Application of a novel tool for diagnosing bile acid diarrhoea. Sensors, Volume 13 (Number 9). pp. 11899-11912. doi:10.3390/s130911899
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WRAP_Covington_sensors-13-11899.pdf - Published Version Available under License Creative Commons Attribution. Download (925Kb) | Preview |
Official URL: http://dx.doi.org/10.3390/s130911899
Abstract
Bile acid diarrhoea (BAD) is a common disease that requires expensive imaging to diagnose. We have tested the efficacy of a new method to identify BAD, based on the detection of differences in volatile organic compounds (VOC) in urine headspace of BAD vs. ulcerative colitis and healthy controls. A total of 110 patients were recruited; 23 with BAD, 42 with ulcerative colitis (UC) and 45 controls. Patients with BAD also received standard imaging (Se75HCAT) for confirmation. Urine samples were collected and the headspace analysed using an AlphaMOS Fox 4000 electronic nose in combination with an Owlstone Lonestar Field Asymmetric Ion Mobility Spectrometer (FAIMS). A subset was also tested by gas chromatography, mass spectrometry (GCMS). Linear Discriminant Analysis (LDA) was used to explore both the electronic nose and FAIMS data. LDA showed statistical differences between the groups, with reclassification success rates (using an n-1 approach) at typically 83%. GCMS experiments confirmed these results and showed that patients with BAD had two chemical compounds, 2-propanol and acetamide, that were either not present or were in much reduced quantities in the ulcerative colitis and control samples. We believe that this work may lead to a new tool to diagnose BAD, which is cheaper, quicker and easier that current methods.
| Item Type: | Journal Article | ||||
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| Subjects: | R Medicine > R Medicine (General) | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||
| Library of Congress Subject Headings (LCSH): | Bile acids, Diarrhea , Intestines -- Diseases, Malabsorption syndromes, Clinical trials | ||||
| Journal or Publication Title: | Sensors | ||||
| Publisher: | MDPI AG | ||||
| ISSN: | 1424-8220 | ||||
| Official Date: | 2013 | ||||
| Dates: |
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| Volume: | Volume 13 | ||||
| Number: | Number 9 | ||||
| Page Range: | pp. 11899-11912 | ||||
| DOI: | 10.3390/s130911899 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access | ||||
| Funder: | Bardhan Research and Education Trust (BRET) |
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