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Application of a novel tool for diagnosing bile acid diarrhoea

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Covington, James A., Westenbrink, Eric W., Ouaret, Nathalie, Harbord, Ruth, Bailey, Catherine, O'Connell, Nicola, Cullis, James, Williams, Nigel, Nwokolo, Chuka U., Bardhan, Karna Dev and Arasaradnam, Ramesh P. (2013) Application of a novel tool for diagnosing bile acid diarrhoea. Sensors, Volume 13 (Number 9). pp. 11899-11912. doi:10.3390/s130911899

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Official URL: http://dx.doi.org/10.3390/s130911899

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Abstract

Bile acid diarrhoea (BAD) is a common disease that requires expensive imaging to diagnose. We have tested the efficacy of a new method to identify BAD, based on the detection of differences in volatile organic compounds (VOC) in urine headspace of BAD vs. ulcerative colitis and healthy controls. A total of 110 patients were recruited; 23 with BAD, 42 with ulcerative colitis (UC) and 45 controls. Patients with BAD also received standard imaging (Se75HCAT) for confirmation. Urine samples were collected and the headspace analysed using an AlphaMOS Fox 4000 electronic nose in combination with an Owlstone Lonestar Field Asymmetric Ion Mobility Spectrometer (FAIMS). A subset was also tested by gas chromatography, mass spectrometry (GCMS). Linear Discriminant Analysis (LDA) was used to explore both the electronic nose and FAIMS data. LDA showed statistical differences between the groups, with reclassification success rates (using an n-1 approach) at typically 83%. GCMS experiments confirmed these results and showed that patients with BAD had two chemical compounds, 2-propanol and acetamide, that were either not present or were in much reduced quantities in the ulcerative colitis and control samples. We believe that this work may lead to a new tool to diagnose BAD, which is cheaper, quicker and easier that current methods.

Item Type: Journal Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Science, Engineering and Medicine > Engineering > Engineering
Library of Congress Subject Headings (LCSH): Bile acids, Diarrhea , Intestines -- Diseases, Malabsorption syndromes, Clinical trials
Journal or Publication Title: Sensors
Publisher: MDPI AG
ISSN: 1424-8220
Official Date: 2013
Dates:
DateEvent
2013Published
Volume: Volume 13
Number: Number 9
Page Range: pp. 11899-11912
DOI: 10.3390/s130911899
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Bardhan Research and Education Trust (BRET)

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