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Group- and genotype-specific neutralizing antibody responses against respiratory syncytial virus in infants and young children with severe pneumonia
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Sande, C. J., Mutunga, M. N., Medley, Graham, Cane, Patricia and Nokes, D. James (2013) Group- and genotype-specific neutralizing antibody responses against respiratory syncytial virus in infants and young children with severe pneumonia. Journal of Infectious Diseases, Volume 207 (Number 3). pp. 489-492. doi:10.1093/infdis/jis700 ISSN 0022-1899.
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Official URL: http://dx.doi.org/10.1093/infdis/jis700
Abstract
The effect of genetic variation on the neutralizing antibody response to respiratory syncytial virus (RSV) is poorly understood. In this study, acute- and convalescent-phase sera were evaluated against different RSV strains. The proportion of individuals with homologous seroconversion was greater than that among individuals with heterologous seroconversion among those infected with RSV group A (50% vs 12.5%; P = .0005) or RSV group B (40% vs 8%; P = .008). Seroconversion to BA genotype or non-BA genotype test viruses was similar among individuals infected with non-BA virus (35% vs 50%; P = .4) or BA virus (50% vs 65%; P = .4). The RSV neutralizing response is group specific. The BA-associated genetic change did not confer an ability to escape neutralizing responses to previous non-BA viruses.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | Journal of Infectious Diseases | ||||
Publisher: | Oxford University Press | ||||
ISSN: | 0022-1899 | ||||
Official Date: | February 2013 | ||||
Dates: |
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Volume: | Volume 207 | ||||
Number: | Number 3 | ||||
Page Range: | pp. 489-492 | ||||
DOI: | 10.1093/infdis/jis700 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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