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Group- and genotype-specific neutralizing antibody responses against respiratory syncytial virus in infants and young children with severe pneumonia

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Sande, C. J., Mutunga, M. N., Medley, Graham, Cane, Patricia and Nokes, D. James (2013) Group- and genotype-specific neutralizing antibody responses against respiratory syncytial virus in infants and young children with severe pneumonia. Journal of Infectious Diseases, Volume 207 (Number 3). pp. 489-492. doi:10.1093/infdis/jis700

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Official URL: http://dx.doi.org/10.1093/infdis/jis700

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Abstract

The effect of genetic variation on the neutralizing antibody response to respiratory syncytial virus (RSV) is poorly understood. In this study, acute- and convalescent-phase sera were evaluated against different RSV strains. The proportion of individuals with homologous seroconversion was greater than that among individuals with heterologous seroconversion among those infected with RSV group A (50% vs 12.5%; P = .0005) or RSV group B (40% vs 8%; P = .008). Seroconversion to BA genotype or non-BA genotype test viruses was similar among individuals infected with non-BA virus (35% vs 50%; P = .4) or BA virus (50% vs 65%; P = .4). The RSV neutralizing response is group specific. The BA-associated genetic change did not confer an ability to escape neutralizing responses to previous non-BA viruses.

Item Type: Journal Article
Divisions: Faculty of Science > Life Sciences (2010- )
Journal or Publication Title: Journal of Infectious Diseases
Publisher: Oxford University Press
ISSN: 0022-1899
Official Date: February 2013
Dates:
DateEvent
February 2013Published
Volume: Volume 207
Number: Number 3
Page Range: pp. 489-492
DOI: 10.1093/infdis/jis700
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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