Sande, C. J., Mutunga, M. N., Medley, Graham, Cane, Patricia and Nokes, D. James (2013) Group- and genotype-specific neutralizing antibody responses against respiratory syncytial virus in infants and young children with severe pneumonia. Journal of Infectious Diseases, Volume 207 (Number 3). pp. 489-492. doi:10.1093/infdis/jis700

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Abstract

The effect of genetic variation on the neutralizing antibody response to respiratory syncytial virus (RSV) is poorly understood. In this study, acute- and convalescent-phase sera were evaluated against different RSV strains. The proportion of individuals with homologous seroconversion was greater than that among individuals with heterologous seroconversion among those infected with RSV group A (50% vs 12.5%; P = .0005) or RSV group B (40% vs 8%; P = .008). Seroconversion to BA genotype or non-BA genotype test viruses was similar among individuals infected with non-BA virus (35% vs 50%; P = .4) or BA virus (50% vs 65%; P = .4). The RSV neutralizing response is group specific. The BA-associated genetic change did not confer an ability to escape neutralizing responses to previous non-BA viruses.

Item Type:	Journal Article
Divisions:	Faculty of Science > Life Sciences (2010- )
Journal or Publication Title:	Journal of Infectious Diseases
Publisher:	Oxford University Press
ISSN:	0022-1899
Official Date:	February 2013
Dates:	Date Event February 2013 Published
Volume:	Volume 207
Number:	Number 3
Page Range:	pp. 489-492
DOI:	10.1093/infdis/jis700
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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