Lewis, Laura Ann (2012) Investigating the influence of phytopathogenic effectors upon host transcription. PhD thesis, University of Warwick.

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Abstract

Phytopathogens have developed methods to suppress, manipulate and avoid host
defences though the production of toxins and proteins that act on the exterior and
interior of host cells. Pathogenic proteins that promote susceptibility to the pathogen
are termed effectors, and can function through the suppression of host defences and the
diversion of host nutrients. Plants are able to detect select effectors, and thus regain
resistance. This multilayered defence response and diverse array of pathogenic effectors
can cause the outcome of infection to be decided by a single protein from either organism.
Current characterised effectors are able to block pathogen-associated molecular pattern
recognition, downstream signalling, up-regulate susceptibility genes including nutrient
transporters, modify chromatin structure, interfere with RNA metabolism, suppress or
prevent effector-triggered immunity and block the defensive and culminating plant cell
death. Research conducted here aims to investigate the in
uence of effectors from two
pathogens upon transcription in their common host, Arabidopsis thaliana.
Over 30 Pseudomonas syringae pv. tomato (Pst) DC3000 effectors, which are
delivered directly into the host cell, have been at least partially characterised with several
more predicted from the sequenced genome. The research presented here analyses
a high resolution microarray time series dataset, comparing the transcriptional events
that take place during virulent Pst DC3000 infection to infection with an avirulent
mutant that is unable to deliver effectors into the host cell; Pst HrpA

Item Type:	Thesis (PhD)
Subjects:	Q Science > QK Botany Q Science > QR Microbiology
Library of Congress Subject Headings (LCSH):	Phytopathogenic bacteria, Arabidopsis thaliana -- Diseases and pests, Viral proteins, Transcription factors, Host-virus relationships
Official Date:	September 2012
Dates:	Date Event September 2012 Submitted
Institution:	University of Warwick
Theses Department:	Systems Biology Doctoral Training Centre
Thesis Type:	PhD
Publication Status:	Unpublished
Supervisor(s)/Advisor:	Beynon, Jim, 1956-
Sponsors:	Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)
Extent:	xv, 192 pages : illustrations, charts.
Language:	eng

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