Tindjong, Rodrigue, Kaufman, Igor, Luchinsky, Dmitrii G., McClintock, P. V. E., Khovanov, I. A. and Eisenberg, Robert S. (2013) Stochastic dynamics of remote knock-on permeation in biological ion channels. In: 22nd International Conference on Noise and Fluctuations (ICNF), Montpellier, France, 24-28 June 2013. Published in: Noise and Fluctuations (ICNF), 2013 22nd International Conference on pp. 1-4. ISBN 978-1-4799-0668-0. doi:10.1109/ICNF.2013.6578893

Preview

Text WRAP_Khovanov_ieee_proc_preprint.pdf - Accepted Version Download (362Kb) | Preview

Request Changes to record.

Abstract

Brownian dynamics simulations provide evidence for a remote knock-on mechanism facilitating the permeation of a biological ion channel by an ion that is initially trapped at the selectivity filter (SF). Unlike the case of conventional direct knock-on, the second ion that instigates permeation does not need to enter the channel. Nor does it necessarily take the place of the permeating ion at the SF, and it can even be of a different ionic species. The study is based on the simultaneous, self-consistent, solution of the coupled Poisson and Langevin equations for a simple generic model, taking account of all the charges present. The new permeation mechanism involves electrostatic amplification attributable to the permittivity mismatch between water and protein: the arrival of the instigating ion at the channel entrance reduces the exit barrier for the ion trapped at the SF, facilitating escape.

Item Type:	Conference Item (Paper)
Subjects:	Q Science > QC Physics Q Science > QH Natural history > QH301 Biology
Divisions:	Faculty of Science > Engineering
Library of Congress Subject Headings (LCSH):	Biophysics, Ion channels, Potassium channels, Ion-permeable membranes
Journal or Publication Title:	Noise and Fluctuations (ICNF), 2013 22nd International Conference on
Publisher:	IEEE
ISBN:	978-1-4799-0668-0
Book Title:	2013 22nd International Conference on Noise and Fluctuations (ICNF)
Official Date:	2013
Dates:	Date Event 2013 Published
Page Range:	pp. 1-4
DOI:	10.1109/ICNF.2013.6578893
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC)
Grant number:	EP/G070660/1 (EPSRC)
Conference Paper Type:	Paper
Title of Event:	22nd International Conference on Noise and Fluctuations (ICNF)
Type of Event:	Conference
Location of Event:	Montpellier, France
Date(s) of Event:	24-28 June 2013

Request changes or add full text files to a record

Repository staff actions (login required)

View Item

Downloads