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Stochastic dynamics of remote knock-on permeation in biological ion channels
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Tindjong, Rodrigue, Kaufman, Igor, Luchinsky, Dmitrii G., McClintock, P. V. E., Khovanov, I. A. and Eisenberg, Robert S. (2013) Stochastic dynamics of remote knock-on permeation in biological ion channels. In: 22nd International Conference on Noise and Fluctuations (ICNF), Montpellier, France, 24-28 June 2013. Published in: Noise and Fluctuations (ICNF), 2013 22nd International Conference on pp. 1-4. ISBN 978-1-4799-0668-0. doi:10.1109/ICNF.2013.6578893
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Official URL: http://dx.doi.org/10.1109/ICNF.2013.6578893
Abstract
Brownian dynamics simulations provide evidence for a remote knock-on mechanism facilitating the permeation of a biological ion channel by an ion that is initially trapped at the selectivity filter (SF). Unlike the case of conventional direct knock-on, the second ion that instigates permeation does not need to enter the channel. Nor does it necessarily take the place of the permeating ion at the SF, and it can even be of a different ionic species. The study is based on the simultaneous, self-consistent, solution of the coupled Poisson and Langevin equations for a simple generic model, taking account of all the charges present. The new permeation mechanism involves electrostatic amplification attributable to the permittivity mismatch between water and protein: the arrival of the instigating ion at the channel entrance reduces the exit barrier for the ion trapped at the SF, facilitating escape.
| Item Type: | Conference Item (Paper) | ||||
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| Subjects: | Q Science > QC Physics Q Science > QH Natural history > QH301 Biology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||
| Library of Congress Subject Headings (LCSH): | Biophysics, Ion channels, Potassium channels, Ion-permeable membranes | ||||
| Journal or Publication Title: | Noise and Fluctuations (ICNF), 2013 22nd International Conference on | ||||
| Publisher: | IEEE | ||||
| ISBN: | 978-1-4799-0668-0 | ||||
| Book Title: | 2013 22nd International Conference on Noise and Fluctuations (ICNF) | ||||
| Official Date: | 2013 | ||||
| Dates: |
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| Page Range: | pp. 1-4 | ||||
| DOI: | 10.1109/ICNF.2013.6578893 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Engineering and Physical Sciences Research Council (EPSRC) | ||||
| Grant number: | EP/G070660/1 (EPSRC) | ||||
| Conference Paper Type: | Paper | ||||
| Title of Event: | 22nd International Conference on Noise and Fluctuations (ICNF) | ||||
| Type of Event: | Conference | ||||
| Location of Event: | Montpellier, France | ||||
| Date(s) of Event: | 24-28 June 2013 |
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