Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

An RxLR effector from phytophthora infestans prevents re-localisation of two plant NAC transcription factors from the endoplasmic reticulum to the nucleus

Tools
- Tools
+ Tools

McLellan, Hazel, Boevink, Petra C., Armstrong, Miles R., Pritchard, Leighton, Gómez-Galera, Sonia, Morales, Juan, Whisson, Stephen C., Beynon, Jim and Birch, Paul R. J. (2013) An RxLR effector from phytophthora infestans prevents re-localisation of two plant NAC transcription factors from the endoplasmic reticulum to the nucleus. PLoS Pathogens, Volume 9 (Number 10). Article number e1003670. doi:10.1371/journal.ppat.1003670 ISSN 1553-7374.

[img]
Preview
Text
WRAP_Beynon_journal.ppat.1003670.pdf - Published Version
Available under License Creative Commons Attribution.

Download (7Mb) | Preview
Official URL: http://dx.doi.org/10.1371/journal.ppat.1003670

Request Changes to record.

Abstract

The plant immune system is activated following the perception of exposed, essential and invariant microbial molecules that are recognised as non-self. A major component of plant immunity is the transcriptional induction of genes involved in a wide array of defence responses. In turn, adapted pathogens deliver effector proteins that act either inside or outside plant cells to manipulate host processes, often through their direct action on plant protein targets. To date, few effectors have been shown to directly manipulate transcriptional regulators of plant defence. Moreover, little is known generally about the modes of action of effectors from filamentous (fungal and oomycete) plant pathogens. We describe an effector, called Pi03192, from the late blight pathogen Phytophthora infestans, which interacts with a pair of host transcription factors at the endoplasmic reticulum (ER) inside plant cells. We show that these transcription factors are released from the ER to enter the nucleus, following pathogen perception, and are important in restricting disease. Pi03192 prevents the plant transcription factors from accumulating in the host nucleus, revealing a novel means of enhancing host susceptibility.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QK Botany
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Phytophthora infestans, Endoplasmic reticulum, Transcription factors, Proteins
Journal or Publication Title: PLoS Pathogens
Publisher: Public Library of Science
ISSN: 1553-7374
Official Date: 2013
Dates:
DateEvent
2013Published
Volume: Volume 9
Number: Number 10
Page Range: Article number e1003670
DOI: 10.1371/journal.ppat.1003670
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 25 December 2015
Date of first compliant Open Access: 25 December 2015
Funder: Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)
Grant number: BB/G015244/1

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us