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An RxLR effector from phytophthora infestans prevents re-localisation of two plant NAC transcription factors from the endoplasmic reticulum to the nucleus
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McLellan, Hazel, Boevink, Petra C., Armstrong, Miles R., Pritchard, Leighton, Gómez-Galera, Sonia, Morales, Juan, Whisson, Stephen C., Beynon, Jim and Birch, Paul R. J. (2013) An RxLR effector from phytophthora infestans prevents re-localisation of two plant NAC transcription factors from the endoplasmic reticulum to the nucleus. PLoS Pathogens, Volume 9 (Number 10). Article number e1003670. doi:10.1371/journal.ppat.1003670
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WRAP_Beynon_journal.ppat.1003670.pdf - Published Version Available under License Creative Commons Attribution. Download (7Mb) | Preview |
Official URL: http://dx.doi.org/10.1371/journal.ppat.1003670
Abstract
The plant immune system is activated following the perception of exposed, essential and invariant microbial molecules that are recognised as non-self. A major component of plant immunity is the transcriptional induction of genes involved in a wide array of defence responses. In turn, adapted pathogens deliver effector proteins that act either inside or outside plant cells to manipulate host processes, often through their direct action on plant protein targets. To date, few effectors have been shown to directly manipulate transcriptional regulators of plant defence. Moreover, little is known generally about the modes of action of effectors from filamentous (fungal and oomycete) plant pathogens. We describe an effector, called Pi03192, from the late blight pathogen Phytophthora infestans, which interacts with a pair of host transcription factors at the endoplasmic reticulum (ER) inside plant cells. We show that these transcription factors are released from the ER to enter the nucleus, following pathogen perception, and are important in restricting disease. Pi03192 prevents the plant transcription factors from accumulating in the host nucleus, revealing a novel means of enhancing host susceptibility.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QK Botany |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||
| Library of Congress Subject Headings (LCSH): | Phytophthora infestans, Endoplasmic reticulum, Transcription factors, Proteins | ||||
| Journal or Publication Title: | PLoS Pathogens | ||||
| Publisher: | Public Library of Science | ||||
| ISSN: | 1553-7374 | ||||
| Official Date: | 2013 | ||||
| Dates: |
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| Date of first compliant deposit: | 25 December 2015 | ||||
| Volume: | Volume 9 | ||||
| Number: | Number 10 | ||||
| Page Range: | Article number e1003670 | ||||
| DOI: | 10.1371/journal.ppat.1003670 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access | ||||
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) | ||||
| Grant number: | BB/G015244/1 |
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