The Library
Meta-regression with partial information on summary trial or patient characteristics
Tools
Tools
Tools
Hemming, Karla, Hutton, Jane, Maguire, M. J. and Marson, A. G. (2010) Meta-regression with partial information on summary trial or patient characteristics. Statistics in Medicine, Vol.29 (No.12). pp. 1312-1324. doi:10.1002/sim.3848 ISSN 0277-6715.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1002/sim.3848
Abstract
We present a model for meta-regression in the presence of missing information on some of the study level covariates, obtaining inferences using Bayesian methods. In practice, when confronted with missing covariate data in a meta-regression, it is common to carry out a complete case or available case analysis. We propose to use the full observed data, modelling the joint density as a factorization of a meta-regression model and a conditional factorization of the density for the covariates. With the inclusion of several covariates, inter-relations between these covariates are modelled. Under this joint likelihood-based approach, it is shown that the lesser assumption of the covariates being Missing At Random is imposed, instead of the more usual Missing Completely At Random (MCAR) assumption. The model is easily programmable in WinBUGS, and we examine, through the analysis of two real data sets, sensitivity and robustness of results to the MCAR assumption. Copyright (C) 2010 John Wiley & Sons, Ltd.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine Q Science > QA Mathematics |
||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Statistics | ||||
| Journal or Publication Title: | Statistics in Medicine | ||||
| Publisher: | John Wiley & Sons Ltd. | ||||
| ISSN: | 0277-6715 | ||||
| Official Date: | 30 May 2010 | ||||
| Dates: |
|
||||
| Volume: | Vol.29 | ||||
| Number: | No.12 | ||||
| Number of Pages: | 13 | ||||
| Page Range: | pp. 1312-1324 | ||||
| DOI: | 10.1002/sim.3848 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Medical Research, National Institute for Health Research (NIHR) | ||||
| Grant number: | G0400642 |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
