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Site-specific identification of an Aβ fibril-heparin interaction site by using solid-state NMR spectroscopy
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Madine, Jillian, Pandya, Maya J., Hicks, Matthew R., Rodger, Alison, Yates, Edwin A., Radford, S. E. (Sheena E.) and Middleton, David A. (2012) Site-specific identification of an Aβ fibril-heparin interaction site by using solid-state NMR spectroscopy. Angewandte Chemie International Edition, Volume 51 (Number 52). pp. 13140-13143. doi:10.1002/anie.201204459 ISSN 1433-7851.
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Official URL: http://dx.doi.org/10.1002/anie.201204459
Abstract
At the surface of Aβ1-40 amyloid fibrils that have a threefold molecular symmetry (green in the left picture) a site of interaction of the glycosaminoglycan analogue heparin (blue) was identified. The binding site consists of residues at the N terminus and the turn regions defining the apices of the triangular geometry. Heparin has a lower affinity for Aβ1-40 fibrils having twofold molecular symmetry, thus revealing a remarkable morphological selectivity.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Alzheimer's disease, Heparin, Nuclear magnetic resonance spectroscopy | ||||
Journal or Publication Title: | Angewandte Chemie International Edition | ||||
Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||
ISSN: | 1433-7851 | ||||
Official Date: | 21 December 2012 | ||||
Dates: |
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Volume: | Volume 51 | ||||
Number: | Number 52 | ||||
Page Range: | pp. 13140-13143 | ||||
DOI: | 10.1002/anie.201204459 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 25 December 2015 | ||||
Date of first compliant Open Access: | 25 December 2015 | ||||
Funder: | Wellcome Trust (London, England) | ||||
Grant number: | 088563/B/09/Z (WT) |
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