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The increase of the functional entropy of the human brain with age
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Yao, Y., Lu, W. L., Xu, B., Li, C. B., Lin, C. P., Waxman, D. (David) and Feng, Jianfeng (2013) The increase of the functional entropy of the human brain with age. Scientific Reports, Volume 3 . Article number 2853. doi:10.1038/srep02853
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Official URL: http://dx.doi.org/10.1038/srep02853
Abstract
We use entropy to characterize intrinsic ageing properties of the human brain. Analysis of fMRI data from a large dataset of individuals, using resting state BOLD signals, demonstrated that a functional entropy associated with brain activity increases with age. During an average lifespan, the entropy, which was calculated from a population of individuals, increased by approximately 0.1 bits, due to correlations in BOLD activity becoming more widely distributed. We attribute this to the number of excitatory neurons and the excitatory conductance decreasing with age. Incorporating these properties into a computational model leads to quantitatively similar results to the fMRI data. Our dataset involved males and females and we found significant differences between them. The entropy of males at birth was lower than that of females. However, the entropies of the two sexes increase at different rates, and intersect at approximately 50 years; after this age, males have a larger entropy.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QH Natural history > QH301 Biology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
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| Divisions: | Faculty of Science > Computer Science | ||||
| Library of Congress Subject Headings (LCSH): | Aging, Developmental neurobiology, Bioinformatics, Systems biology, Computational biology | ||||
| Journal or Publication Title: | Scientific Reports | ||||
| Publisher: | Nature Publishing Group | ||||
| ISSN: | 2045-2322 | ||||
| Official Date: | October 2013 | ||||
| Dates: |
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| Date of first compliant deposit: | 25 December 2015 | ||||
| Volume: | Volume 3 | ||||
| Page Range: | Article number 2853 | ||||
| DOI: | 10.1038/srep02853 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access | ||||
| Funder: | China Scholarship Council (CSC), Royal Society (Great Britain), Zhongguo ke xue yuan [Chinese Academy of Sciences] (CAS), Marie Curie Fellowship Association (MCFA), European Commission (EC), Guo jia zi ran ke xue ji jin wei yuan hui (China) [National Natural Science Foundation of China] (NSFC), Foundation for the Author of National Excellent Doctoral Dissertation (China), Shanghai Rising-Star Program (SRSP), Fu dan da xue (Shanghai, China) [Fudan University], Guo li zhong yang da xue (Chung-li, Taiwan) [National Central University] (NCU) | ||||
| Grant number: | 91230201 (CAS) ; FP7-PEOPLE-2011-IIF-302421 (EC) ; 61273309, 30770769 (NSFC) ; 200921 (FANEDD) ; 11QA1400400 (SRSP) ; NSC 101-2911-I-008-001 (NCU) |
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