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Exploring the relationship between baseline physical activity levels and mortality reduction associated with increases in physical activity : a modelling study
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Minton, J. (Jonathan), Dimairo, Munyaradzi, Everson-Hock, Emma, Scott, Emma and Goyder, Elizabeth (2013) Exploring the relationship between baseline physical activity levels and mortality reduction associated with increases in physical activity : a modelling study. BMJ Open, Volume 3 (Number 10). Article number e003509. doi:10.1136/bmjopen-2013-003509 ISSN 2044-6055.
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WRAP_Scott_BMJ Open-2013-Minton-.pdf - Published Version Available under License Creative Commons Attribution Non-commercial. Download (1073Kb) | Preview |
Official URL: http://dx.doi.org/10.1136/bmjopen-2013-003509
Abstract
Background Increasing physical activity (PA) levels among the general adult population of developed nations is important for reducing premature mortality and the burdens of preventable illness. Assessing how effective PA interventions are as health interventions often involves categorising participants as either ‘active’ or ‘sedentary’ after the interventions. A model was developed showing that doing this could significantly misestimate the health effect of PA interventions.
Methods A life table model was constructed combining evidence on baseline PA levels with evidence indicating the non-linear relationship between PA levels and all-cause mortality risks. PA intervention scenarios were modelled which had the same mean increase in PA but different levels of take-up by people who were more active or more sedentary to begin with.
Results The model simulations indicated that, compared with a scenario where already-active people did most of the additional PA, a scenario where the least active did the most additional PA was around a third more effective in preventing deaths between the ages of 50 and 60 years. The relationship between distribution of PA take-up and health effect was explored systematically and appeared non-linear.
Conclusions As the health gains of a given PA increase are greatest among people who are most sedentary, smaller increases in PA in the least active may have the same health benefits as much larger PA increases in the most active. To help such health effects to be assessed, PA studies should report changes in the distribution of PA level between the start and end of the study.
| Item Type: | Journal Article | ||||
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| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Exercise -- Physiological aspects, Mortality, Health promotion, Sedentary behavior -- Health aspects | ||||
| Journal or Publication Title: | BMJ Open | ||||
| Publisher: | BMJ | ||||
| ISSN: | 2044-6055 | ||||
| Official Date: | 2013 | ||||
| Dates: |
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| Volume: | Volume 3 | ||||
| Number: | Number 10 | ||||
| Page Range: | Article number e003509 | ||||
| DOI: | 10.1136/bmjopen-2013-003509 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||
| Date of first compliant deposit: | 25 December 2015 | ||||
| Date of first compliant Open Access: | 25 December 2015 | ||||
| Funder: | NIHR Health Technology Assessment Programme (Great Britain) | ||||
| Grant number: | HTA 07/25/02 (NIHR HTAP) |
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