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Serum resistin is associated with C-reactive protein and LDL- cholesterol in type 2 diabetes and coronary artery disease in a Saudi population
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Al-Daghri, Nasser M., Chetty, R., McTernan, P. G. (Philip G.), Al-Rubean , K., Al-Attas, Omar S., Jones, A. F. and Kumar, Sudhesh (2005) Serum resistin is associated with C-reactive protein and LDL- cholesterol in type 2 diabetes and coronary artery disease in a Saudi population. Cardiovascular Diabetology, Vol.4 (No.10). doi:10.1186/1475-2840-4-10
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Official URL: http://dx.doi.org/10.1186/1475-2840-4-10
Abstract
Aims
Resistin is an adipocyte-derived factor implicated in obesity-associated type 2 diabetes (T2DM). This study examines the association between human serum resistin, T2DM and coronary heart disease.
Methods
One hundred and fourteen Saudi Arabian patients (male: female ratio 46:68; age 51.4 (mean ± SD)11.7 years; median and range: 45.59 (11.7) years and BMI: 27.1 (mean ± SD) 8.1 Kgm2 median and range: 30.3 (6.3) were studied. Serum resistin and C-reactive protein (CRP), a marker of inflammation CRP levels, were measured in all subjects. (35 patients had type 2 diabetes mellitus (T2DM); 22 patients had coronary heart disease (CHD).
Results
Serum resistin levels were 1.2-fold higher in type 2 diabetes and 1.3-fold higher in CHD than in controls (p = 0.01). In addition, CRP was significantly increased in both T2DM and CHD patients (p = 0.007 and p = 0.002 respectively). The use of regression analysis also determined that serum resistin correlated with CRP levels (p = 0.04, R2 0.045).
Conclusion
The findings from this study further implicate resistin as a circulating protein associated with T2DM and CHD. In addition this study also demonstrates an association between resistin and CRP, a marker of inflammation in type 2 diabetic patients.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine | ||||
| Divisions: | Faculty of Medicine > Warwick Medical School | ||||
| Library of Congress Subject Headings (LCSH): | Diabetes -- Saudi Arabia, Coronary heart disease -- Saudi Arabia, Adipose tissues, Cholesterol | ||||
| Journal or Publication Title: | Cardiovascular Diabetology | ||||
| Publisher: | BioMed Central Ltd. | ||||
| ISSN: | 1475-2840 | ||||
| Official Date: | 5 July 2005 | ||||
| Dates: |
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| Volume: | Vol.4 | ||||
| Number: | No.10 | ||||
| DOI: | 10.1186/1475-2840-4-10 | ||||
| Status: | Peer Reviewed | ||||
| Access rights to Published version: | Open Access |
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