Schoemaker, Minouk J., Robertson, Lindsay, Wigertz, Annette, Jones, Michael E., Hosking, Fay J., Feychting, Maria, Lonn, Stefan, McKinney, Patricia A., Hepworth, Sarah J., Muir, Kenneth (Kenneth R.), Auvinen, Anssi, Salminen, Tiina, Kiuru, Anne, Johansen, Christoffer, Houlston, Richard S. and Swerdlow, Anthony J.. (2010) Interaction between 5 genetic variants and allergy in glioma risk. American Journal of Epidemiology, Vol.171 (No.11). pp. 1165-1173. ISSN 0002-9262

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Abstract

The etiology of glioma is barely known. Epidemiologic studies have provided evidence for an inverse relation between glioma risk and allergic disease. Genome-wide association data have identified common genetic variants at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 11q23.3 (rs498872, PHLDB1), and 20q13.33 (rs6010620, RTEL1) as determinants of glioma risk. The authors investigated whether there is interaction between the effects of allergy and these 5 variants on glioma risk. Data from 5 case-control studies carried out in Denmark, Finland, Sweden, and the United Kingdom (2000-2004) were used, totaling 1,029 cases and 1,668 controls. Risk was inversely associated with asthma, hay fever, eczema, and "any allergy," significantly for each factor except asthma, and was significantly positively associated with number of risk alleles for each of the 5 single nucleotide polymorphisms. There was interaction between asthma and rs498872 (greater protective effect of asthma with increasing number of risk alleles; per-allele interaction odds ratio (OR) = 0.65, P = 0.041), between "any allergy" and rs4977756 (smaller protective effect; interaction OR = 1.27, P = 0.047), and between "any allergy" and rs6010620 (greater protective effect; interaction OR = 0.70, P = 0.017). Case-only analyses provided further support for atopy interactions for rs4977756 and rs498872. This study provides evidence for possible gene-environment interactions in glioma development.

Item Type:	Journal Article
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	American Journal of Epidemiology
Publisher:	Oxford University Press
ISSN:	0002-9262
Date:	1 June 2010
Volume:	Vol.171
Number:	No.11
Number of Pages:	9
Page Range:	pp. 1165-1173
Identification Number:	10.1093/aje/kwq075
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	European Commission, International Union Against Cancer, Mobile Telecommunications and Health Programme, Wellcome Trust, Cancer Research UK, European Union, United Kingdom Health and Safety Executive, United Kingdom Department of Health, Scottish Executive, Danish Cancer Society, Emil Aaltonen Foundation, Academy of Finland, Swedish Research Council, Swedish Cancer Society, United Kingdom National Health Service, through the NIHR Biomedical Research Centre, O2, UK, Orange, UK, T-Mobile, UK, Vodafone, UK, "3", UK
Grant number:	QLK4-CT-1999-01563, RCA/01/08, C1298/A8362, CPRB LSHC-CT-2004-503465, 80921
URI:	http://wrap.warwick.ac.uk/id/eprint/5796

Data sourced from Thomson Reuters' Web of Knowledge

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