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Functional cardiovascular reserve predicts survival pre-kidney and post-kidney transplantation
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Ting, Stephen M. S., Iqbal, H., Kanji, H., Hamborg, Thomas, Aldridge, N., Krishnan, N., Imray, C. (Chris), Banerjee, P., Bland, Rosemary, Higgins, Rob and Zehnder, Daniel (2014) Functional cardiovascular reserve predicts survival pre-kidney and post-kidney transplantation. Journal of the American Society of Nephrology, Volume 25 (Number 1). pp. 187-195. doi:10.1681/ASN.2013040348 ISSN 1046-6673.
An open access version can be found in:
Official URL: http://dx.doi.org/10.1681/ASN.2013040348
Abstract
Exercise intolerance is an important comorbidity in patients with CKD. Anaerobic threshold (AT) determines the upper limits of aerobic exercise and is a measure of cardiovascular reserve. This study investigated the prognostic capacity of AT on survival in patients with advanced CKD and the effect of kidney transplantation on survival in those with reduced cardiovascular reserve. Using cardiopulmonary exercise testing, cardiovascular reserve was evaluated in 240 patients who were waitlisted for kidney transplantation between 2008 and 2010, and patients were followed for ≤5 years. Survival time was the primary endpoint. Cumulative survival for the entire cohort was 72.6% (24 deaths), with cardiovascular events being the most common cause of death (54.2%). According to Kaplan–Meier estimates, patients with AT <40% of predicted peak VO2 had a significantly reduced 5-year cumulative overall survival rate compared with those with AT ≥40% (P<0.001). Regarding the cohort with AT <40%, patients who underwent kidney transplantation (6 deaths) had significantly better survival compared with nontransplanted patients (17 deaths) (hazard ratio, 4.48; 95% confidence interval, 1.78 to 11.38; P=0.002). Survival did not differ significantly among patients with AT ≥40%, with one death in the nontransplanted group and no deaths in the transplanted group. In summary, this is the first prospective study to demonstrate a significant association of AT, as the objective index of cardiovascular reserve, with survival in patients with advanced CKD. High-risk patients with reduced cardiovascular reserve had a better survival rate after receiving a kidney transplant.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Journal of the American Society of Nephrology | ||||||||
| Publisher: | American Society of Nephrology | ||||||||
| ISSN: | 1046-6673 | ||||||||
| Official Date: | January 2014 | ||||||||
| Dates: |
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| Volume: | Volume 25 | ||||||||
| Number: | Number 1 | ||||||||
| Page Range: | pp. 187-195 | ||||||||
| DOI: | 10.1681/ASN.2013040348 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Open Access Version: |
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