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“Giant surfactants” created by the fast and efficient functionalization of a DNA tetrahedron with a temperature-responsive polymer
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Wilks, Thomas R., Bath, Jonathan, de Vries, Jan Willem, Raymond, Jeffery E., Herrmann, Andreas, Turberfield, Andrew J. and O’Reilly, Rachel K. (2013) “Giant surfactants” created by the fast and efficient functionalization of a DNA tetrahedron with a temperature-responsive polymer. ACS Nano, Volume 7 (Number 10). pp. 8561-8572. doi:10.1021/nn402642a ISSN 1936-0851.
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Official URL: http://dx.doi.org/10.1021/nn402642a
Abstract
Copper catalyzed azide–alkyne cycloaddition (CuAAC) was employed to synthesize DNA block copolymers (DBCs) with a range of polymer blocks including temperature-responsive poly(N-isoproylacrylamide) (poly(NIPAM)) and highly hydrophobic poly(styrene). Exceptionally high yields were achieved at low DNA concentrations, in organic solvents, and in the absence of any solid support. The DNA segment of the DBC remained capable of sequence-specific hybridization: it was used to assemble a precisely defined nanostructure, a DNA tetrahedron, with pendant poly(NIPAM) segments. In the presence of an excess of poly(NIPAM) homopolymer, the tetrahedron–poly(NIPAM) conjugate nucleated the formation of large, well-defined nanoparticles at 40 °C, a temperature at which the homopolymer precipitated from solution. These composite nanoparticles were observed by dynamic light scattering and cryoTEM, and their hybrid nature was confirmed by AFM imaging. As a result of the large effective surface area of the tetrahedron, only very low concentrations of the conjugate were required in order for this surfactant-like behavior to be observed.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Journal or Publication Title: | ACS Nano | ||||
Publisher: | American Chemical Society | ||||
ISSN: | 1936-0851 | ||||
Official Date: | 2013 | ||||
Dates: |
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Volume: | Volume 7 | ||||
Number: | Number 10 | ||||
Page Range: | pp. 8561-8572 | ||||
DOI: | 10.1021/nn402642a | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published |
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