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Host–pathogen interactions : proline gives insect pathogens the green light
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Waterfield, Nicholas R. (2010) Host–pathogen interactions : proline gives insect pathogens the green light. Current Biology, Volume 20 (Number 1). R13-R15. doi:10.1016/j.cub.2009.11.018 ISSN 0960-9822.
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Official URL: http://dx.doi.org/10.1016/j.cub.2009.11.018
Abstract
How does a quiescent symbiont of a nematode worm know when to turn nasty? Metabolic analysis and genetic knockouts confirm that model insect pathogens can sense L-proline in insect blood. This not only serves as a wake-up call, activating secondary metabolite virulence factors, but also provides an energy source for a metabolic shift appropriate for adaptation to the host environment.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Current Biology | ||||
Publisher: | Cell Press | ||||
ISSN: | 0960-9822 | ||||
Official Date: | 2010 | ||||
Dates: |
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Volume: | Volume 20 | ||||
Number: | Number 1 | ||||
Page Range: | R13-R15 | ||||
DOI: | 10.1016/j.cub.2009.11.018 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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