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Morphological transitions in polymer vesicles upon bilayer swelling with small hydrophobic molecules in water
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Parmenter, Christopher D. J., Chen, Rong, Cheung, David L. and Bon, Stefan Antonius Franciscus (2013) Morphological transitions in polymer vesicles upon bilayer swelling with small hydrophobic molecules in water. Soft Matter, Volume 9 (Number 29). pp. 6890-6896. doi:10.1039/c3sm50184a ISSN 1744-683X.
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Official URL: http://dx.doi.org/10.1039/C3SM50184A
Abstract
We show that when unilamellar polymer vesicles dispersed in water made from a blockcopolymer, in this case poly((ethylene oxide)45-block-(methyl methacrylate)164), poly((ethylene oxide)45-block-(methyl methacrylate)170), or poly(n-butyl methacrylate)81-block-(2-(dimethylamino)ethyl methacrylate)20, are exposed to small hydrophobic molecules, here methyl methacrylate as well as n-butyl methacrylate, they can undergo morphological transitions. Upon swelling, the polymersomes lose their original simple bilayer morphology and transform into more complex coil-like and patchy colloidal structures, as investigated experimentally by cryogenic electron microscopy (cryo-EM). Dissipative particle dynamics (DPD) simulations on a model flat bilayer indeed show that transitions can occur upon bilayer swelling, which is accompanied by a change in the mechanical bilayer properties. The transition involves the formation of water pockets in the interior regions of the bilayer. Co-existence of the various morphologies in the experiments suggests an activation barrier towards morphological changes and a possibility of multiple meta-stable states. The latter indeed is supported by the existence of multiple minima in the surface tension as a function of bilayer area, as found in the simulations.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
| Journal or Publication Title: | Soft Matter | ||||
| Publisher: | Royal Society of Chemistry | ||||
| ISSN: | 1744-683X | ||||
| Official Date: | August 2013 | ||||
| Dates: |
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| Volume: | Volume 9 | ||||
| Number: | Number 29 | ||||
| Page Range: | pp. 6890-6896 | ||||
| DOI: | 10.1039/c3sm50184a | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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