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Ethnic and geographic differentiation of helicobacter pylori within Iran
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Latifi-Navid, Saeid, Ghorashi, Seyed Ali, Siavoshi, Farideh, Linz, Bodo, Massarrat, Sadegh, Khegay, Tanya, Salmanian, Ali-Hatef, Shayesteh, Ali Akbar, Masoodi, Mohsen, Ghanadi, Koroush, Ganji, Azita, Suerbaum, Sebastian, Achtman, Mark, Malekzadeh, Reza and Falush, Daniel (2010) Ethnic and geographic differentiation of helicobacter pylori within Iran. PLoS One, Volume 5 (Number 3). Article number e9645. doi:10.1371/journal.pone.0009645 ISSN 1932-6203.
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Official URL: http://dx.doi.org/10.1371/journal.pone.0009645
Abstract
The bacterium Helicobacter pylori colonizes the human stomach, with individual infections persisting for decades. The spread of the bacterium has been shown to reflect both ancient and recent human migrations. We have sequenced housekeeping genes from H. pylori isolated from 147 Iranians with well-characterized geographical and ethnic origins sampled throughout Iran and compared them with sequences from strains from other locations. H. pylori from Iran are similar to others isolated from Western Eurasia and can be placed in the previously described HpEurope population. Despite the location of Iran at the crossroads of Eurasia, we found no evidence that the region been a major source of ancestry for strains across the continent. On a smaller scale, we found genetic affinities between the H. pylori isolated from particular Iranian populations and strains from Turks, Uzbeks, Palestinians and Israelis, reflecting documented historical contacts over the past two thousand years.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QR Microbiology R Medicine > R Medicine (General) |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine |
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| Library of Congress Subject Headings (LCSH): | Helicobacter pylori , Helicobacter pylori infections -- Iran, Pathogenic microorganisms, Genetics | ||||
| Journal or Publication Title: | PLoS One | ||||
| Publisher: | Public Library of Science | ||||
| ISSN: | 1932-6203 | ||||
| Official Date: | 2010 | ||||
| Dates: |
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| Volume: | Volume 5 | ||||
| Number: | Number 3 | ||||
| Page Range: | Article number e9645 | ||||
| DOI: | 10.1371/journal.pone.0009645 | ||||
| Status: | Not Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||
| Funder: | Dānishgāh-i ʻUlūm-i Pizishkī-i Tihrān [Tehran University of Medical Sciences] (DUPT), Scinece Foundtion Ireland, Volkswagenstiftung (VWS) | ||||
| Grant number: | 301/166 (DUPT) ; 05/FE1/B882 (SFI) |
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