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A broad brush, global overview of bacterial sexuality
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Achtman, Mark (2011) A broad brush, global overview of bacterial sexuality. PLoS Genetics, Volume 7 (Number 8). Article number e1002255. doi:10.1371/journal.pgen.1002255
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WRAP_journal.pgen.1002255.pdf - Published Version Available under License Creative Commons Attribution. Download (199Kb) | Preview |
Official URL: http://dx.doi.org/10.1371/journal.pgen.1002255
Abstract
Bacterial sexuality is confusing, even for experts! I used to be such an expert on one mechanism of sexuality, conjugation, but that was over 30 years ago. At that time, extra-chromosomal elements, so-called plasmids, were known to encode multiple proteins that together enabled cell-to-cell contacts, which were then used to transfer single-stranded DNA from donor to recipient, thus providing the plasmid with a new host. Transfer of the plasmid resulted in concomitant transfer of any genes that it happened to include, such as genes encoding resistance to antibiotics or virulence factors. On unusual and rare occasions, the plasmid integrated into the chromosome, resulting in the conjugative transfer of chromosomal DNA. What was particularly confusing was the plethora of plasmids that encoded genes for conjugation, each apparently different from the other, and the corresponding large variety of differences between mechanisms of conjugation associated with different plasmids. Some plasmids didn't even encode genes for conjugation, but simply hitch-hiked with the help of conjugation proteins expressed by other plasmids, a phenomenon called mobilization.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH426 Genetics Q Science > QR Microbiology |
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| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Medicine > Warwick Medical School Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine |
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| Library of Congress Subject Headings (LCSH): | Bacterial genetics, Bacterial genomes, Bacteria -- Physiology, Bacterial growth | ||||
| Journal or Publication Title: | PLoS Genetics | ||||
| Publisher: | Public Library of Science | ||||
| ISSN: | 1553-7390 | ||||
| Official Date: | 2011 | ||||
| Dates: |
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| Date of first compliant deposit: | 26 December 2015 | ||||
| Volume: | Volume 7 | ||||
| Number: | Number 8 | ||||
| Page Range: | Article number e1002255 | ||||
| DOI: | 10.1371/journal.pgen.1002255 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access |
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