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High-throughput bacterial genome sequencing : an embarrassment of choice, a world of opportunity

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Loman, Nicholas J., Constantinidou, Chrystala, Chan, Jacqueline, Halachev, Mihail R., Sergeant, Martin J., Penn, Charles W., Robinson, Esther R. and Pallen, Mark J. (2012) High-throughput bacterial genome sequencing : an embarrassment of choice, a world of opportunity. Nature Reviews Microbiology, 10 (9). pp. 599-606. doi:10.1038/nrmicro2850

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Official URL: http://dx.doi.org/10.1038/nrmicro2850

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Abstract

Here, we take a snapshot of the high-throughput sequencing platforms, together with the relevant analytical tools, that are available to microbiologists in 2012, and evaluate the strengths and weaknesses of these platforms in obtaining bacterial genome sequences. We also scan the horizon of future possibilities, speculating on how the availability of sequencing that is 'too cheap to metre' might change the face of microbiology forever.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Nature Reviews Microbiology
Publisher: Nature Publishing Group
ISSN: 1740-1526
Official Date: 6 August 2012
Dates:
DateEvent
6 August 2012Published
Volume: 10
Number: 9
Page Range: pp. 599-606
DOI: 10.1038/nrmicro2850
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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