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High-throughput bacterial genome sequencing : an embarrassment of choice, a world of opportunity
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Loman, Nicholas J., Constantinidou, Chrystala, Chan, Jacqueline, Halachev, Mihail R., Sergeant, Martin J., Penn, Charles W., Robinson, Esther R. and Pallen, Mark J. (2012) High-throughput bacterial genome sequencing : an embarrassment of choice, a world of opportunity. Nature Reviews Microbiology, 10 (9). pp. 599-606. doi:10.1038/nrmicro2850 ISSN 1740-1526.
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Official URL: http://dx.doi.org/10.1038/nrmicro2850
Abstract
Here, we take a snapshot of the high-throughput sequencing platforms, together with the relevant analytical tools, that are available to microbiologists in 2012, and evaluate the strengths and weaknesses of these platforms in obtaining bacterial genome sequences. We also scan the horizon of future possibilities, speculating on how the availability of sequencing that is 'too cheap to metre' might change the face of microbiology forever.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Nature Reviews Microbiology | ||||
| Publisher: | Nature Publishing Group | ||||
| ISSN: | 1740-1526 | ||||
| Official Date: | 6 August 2012 | ||||
| Dates: |
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| Volume: | 10 | ||||
| Number: | 9 | ||||
| Page Range: | pp. 599-606 | ||||
| DOI: | 10.1038/nrmicro2850 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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