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A commensal gone bad : complete genome sequence of the prototypical enterotoxigenic escherichia coli strain H10407
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(2010) A commensal gone bad : complete genome sequence of the prototypical enterotoxigenic escherichia coli strain H10407. Journal of Bacteriology, Volume 192 (Number 21). pp. 5822-5831. doi:10.1128/JB.00710-10 ISSN 0021-9193. An open access version can be found in:
Official URL: http://dx.doi.org/10.1128/JB.00710-10
Abstract
In most cases, Escherichia coli exists as a harmless commensal organism, but it may on occasion cause intestinal and/or extraintestinal disease. Enterotoxigenic E. coli (ETEC) is the predominant cause of E. coli-mediated diarrhea in the developing world and is responsible for a significant portion of pediatric deaths. In this study, we determined the complete genomic sequence of E. coli H10407, a prototypical strain of enterotoxigenic E. coli, which reproducibly elicits diarrhea in human volunteer studies. We performed genomic and phylogenetic comparisons with other E. coli strains, revealing that the chromosome is closely related to that of the nonpathogenic commensal strain E. coli HS and to those of the laboratory strains E. coli K-12 and C. Furthermore, these analyses demonstrated that there were no chromosomally encoded factors unique to any sequenced ETEC strains. Comparison of the E. coli H10407 plasmids with those from several ETEC strains revealed that the plasmids had a mosaic structure but that several loci were conserved among ETEC strains. This study provides a genetic context for the vast amount of experimental and epidemiological data that have been published.
| Item Type: | Journal Article | ||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Journal of Bacteriology | ||||
| Publisher: | American Society for Microbiology | ||||
| ISSN: | 0021-9193 | ||||
| Official Date: | November 2010 | ||||
| Dates: |
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| Volume: | Volume 192 | ||||
| Number: | Number 21 | ||||
| Page Range: | pp. 5822-5831 | ||||
| DOI: | 10.1128/JB.00710-10 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||
| Open Access Version: |
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