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High-throughput whole-genome sequencing to dissect the epidemiology of Acinetobacter baumannii isolates from a hospital outbreak
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Lewis, T., Loman, Nicholas J., Bingle, L., Jumaa, P., Weinstock, G. M., Mortiboy, D. and Pallen, Mark J. (2010) High-throughput whole-genome sequencing to dissect the epidemiology of Acinetobacter baumannii isolates from a hospital outbreak. Journal of Hospital Infection, Volume 75 (Number 1). pp. 37-41. doi:10.1016/j.jhin.2010.01.012
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Official URL: http://dx.doi.org/10.1016/j.jhin.2010.01.012
Abstract
Shared care of military and civilian patients has resulted in transmission of multidrug-resistant Acinetobacter baumannii (MDR-Aci) from military casualties to civilians. Current typing technologies have been useful in revealing relationships between isolates of A. baumannii but they are unable to resolve differences between closely related isolates from small-scale outbreaks, where chains of transmission are often unclear. In a recent hospital outbreak in Birmingham, six patients were colonised with MDR-Aci isolates indistinguishable using standard techniques. We used whole-genome sequencing to identify single nucleotide polymorphisms in these isolates, allowing us to discriminate between alternative epidemiological hypotheses in this setting.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Journal of Hospital Infection | ||||
| Publisher: | W B Saunders Co Ltd. | ||||
| ISSN: | 0195-6701 | ||||
| Official Date: | 2010 | ||||
| Dates: |
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| Volume: | Volume 75 | ||||
| Number: | Number 1 | ||||
| Page Range: | pp. 37-41 | ||||
| DOI: | 10.1016/j.jhin.2010.01.012 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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