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High-throughput sequencing and clinical microbiology : progress, opportunities and challenges
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Pallen, Mark J., Loman, Nicholas J. and Penn, Charles W. (2010) High-throughput sequencing and clinical microbiology : progress, opportunities and challenges. Current Opinion in Microbiology, Volume 13 (Number 5). pp. 625-631. doi:10.1016/j.mib.2010.08.003
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Official URL: http://dx.doi.org/10.1016/j.mib.2010.08.003
Abstract
High-throughput sequencing is sweeping through clinical microbiology, transforming our discipline in its wake. It is already providing an enhanced view of pathogen biology through rapid and inexpensive whole-genome sequencing and more sophisticated applications such as RNA-seq. It also promises to deliver high-resolution genomic epidemiology as the ultimate typing method for bacteria. However, the most revolutionary effect of this ‘disruptive technology’ is likely to be creation of a novel sequence-based, culture-independent diagnostic microbiology that incorporates microbial community profiling, metagenomics and single-cell genomics. We should prepare for the coming ‘technological singularity’ in sequencing, when this technology becomes so fast and so cheap that it threatens to out-compete existing diagnostic and typing methods in microbiology.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Current Opinion in Microbiology | ||||
| Publisher: | Elsevier Ltd | ||||
| ISSN: | 1369-5274 | ||||
| Official Date: | 2010 | ||||
| Dates: |
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| Volume: | Volume 13 | ||||
| Number: | Number 5 | ||||
| Page Range: | pp. 625-631 | ||||
| DOI: | 10.1016/j.mib.2010.08.003 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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