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The homodimeric GBS1074 fromStreptococcus agalactiae
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Shukla, Anshuman, Pallen, Mark J., Anthony, Mark and White, Scott A. (2010) The homodimeric GBS1074 fromStreptococcus agalactiae. Acta Crystallographica Section F Structural Biology and Crystallization Communications, Volume 66 (Number 11). pp. 1421-1425. doi:10.1107/S1744309110036286 ISSN 1744-3091.
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Official URL: http://dx.doi.org/10.1107/S1744309110036286
Abstract
ESAT-6 is a well characterized secreted protein from Mycobacterium tuberculosis and represents the archetype of the WXG100 family of proteins. Genes encoding ESAT-6 homologues have been identified in the genome of the human pathogen Streptococcus agalactiae; one of these genes, esxA, has been cloned and the recombinant protein has been crystallized. In contrast to M. tuberculosis ESAT-6, the crystal structure of GBS1074 reveals a homodimeric structure similar to homologous structures from Staphylococcus aureus and Helicobacter pylori. Intriguingly, GBS1074 forms elongated fibre-like assemblies in the crystal structure.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Acta Crystallographica Section F Structural Biology and Crystallization Communications | ||||
Publisher: | Wiley-Blackwell Publishing, Inc. | ||||
ISSN: | 1744-3091 | ||||
Official Date: | November 2010 | ||||
Dates: |
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Volume: | Volume 66 | ||||
Number: | Number 11 | ||||
Page Range: | pp. 1421-1425 | ||||
DOI: | 10.1107/S1744309110036286 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Open Access Version: |
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