Serum selenium and serum lipids in US adults : National Health and Nutrition Examination Survey (NHANES) 2003-2004
Laclaustra, Martin, Stranges, Saverio, Navas-Acien, Ana, Ordovas, Jose M. and Guallar, Eliseo. (2010) Serum selenium and serum lipids in US adults : National Health and Nutrition Examination Survey (NHANES) 2003-2004. Atherosclerosis, Vol.210 (No.2). pp. 643-648. ISSN 0021-9150Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.atherosclerosis.2010.0...
Objective: High selenium has been recently associated with several cardiovascular and metabolic risk factors including diabetes, blood pressure and lipid levels. We evaluated the association of serum selenium with fasting serum lipid levels in the National Health and Nutrition Examination Survey (NHANES) 2003-2004, the most recently available representative sample of the US population that measured selenium levels.
Methods: Cross-sectional analysis of 1159 adults >= 40 years old from NHANES 2003-2004. Serum selenium was measured by inductively coupled plasma-dynamic reaction cell-mass spectrometry. Fasting serum total cholesterol, triglycerides, and HDL cholesterol were measured enzymatically and LDL cholesterol was calculated.
Results: Mean serum selenium was 136.7 mu g/L. The multivariable adjusted average differences (95% confidence interval) comparing the highest (>= 147 mu g/L) to the lowest (< 124 mu g/L) selenium quartiles were 18.9 (9.9, 28.0) mg/dL for total cholesterol, 12.7 (3.3, 22.2) mg/dL for LDL cholesterol, 3.9 (0.4, 7.5) mg/dL for HDL cholesterol, and 11.5 (-7.6, 30.7) mg/dL for triglycerides. In spline regression models, total and LDL cholesterol levels increased progressively with increasing selenium concentrations. HDL cholesterol increased with selenium but reached a plateau above 120 mu g/L of serum selenium (20th percentile). The triglyceride-selenium relationship was U-shaped.
Conclusion: In US adults, high serum selenium concentrations were associated with increased serum concentrations of total and LDL cholesterol. Selenium was associated with increasing HDL cholesterol only at low selenium levels. Given increasing trends in dietary selenium intake and supplementation, the causal mechanisms underlying these associations need to be fully characterized. (c) 2010 Elsevier Ireland Ltd. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||Q Science > QP Physiology
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
|Divisions:||Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
|Library of Congress Subject Headings (LCSH):||Selenium -- Physiological effect -- Research, Blood lipids, National Health and Nutrition Examination Survey (U.S.), Selenium -- Analysis -- United States -- Statistics, Selenium in human nutrition -- Analysis -- United States -- Statistics|
|Journal or Publication Title:||Atherosclerosis|
|Publisher:||Elsevier Ireland Ltd.|
|Official Date:||June 2010|
|Number of Pages:||6|
|Page Range:||pp. 643-648|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||National Institute of Environmental Health Sciences (NIEHS), National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) (NIDDK), American Heart Association (AHA)|
|Grant number:||ES012673 (NIEHS), DK075030 (NIDDK), 0230232N (AHA)|
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