Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Transport and self-organization across different length scales powered by motor proteins and programmed by DNA

Tools
- Tools
+ Tools

Wollman, Adam J. M., Sanchez-Cano, Carlos, Carstairs, Helen M. J., Cross, R. A. and Turberfield, Andrew J. (2014) Transport and self-organization across different length scales powered by motor proteins and programmed by DNA. Nature Nanotechnology, Volume 9 (Number 1). pp. 44-47. doi:10.1038/nnano.2013.230

Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.1038/nnano.2013.230

Request Changes to record.

Abstract

In eukaryotic cells, cargo is transported on self-organized networks of microtubule trackways by kinesin and dynein motor proteins. Synthetic microtubule networks have previously been assembled in vitro, and microtubules have been used as shuttles to carry cargoes on lithographically defined tracks consisting of surface-bound kinesin motors. Here, we show that molecular signals can be used to program both the architecture and the operation of a self-organized transport system that is based on kinesin and microtubules and spans three orders of magnitude in length scale. A single motor protein, dimeric kinesin-1, is conjugated to various DNA nanostructures to accomplish different tasks. Instructions encoded into the DNA sequences are used to direct the assembly of a polar array of microtubules and can be used to control the loading, active concentration and unloading of cargo on this track network, or to trigger the disassembly of the network.

Item Type: Journal Article
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Nature Nanotechnology
Publisher: Nature Publishing Group
ISSN: 1748-3387
Official Date: 10 November 2014
Dates:
DateEvent
10 November 2014Published
10 November 2013Available
2014Accepted
Volume: Volume 9
Number: Number 1
Page Range: pp. 44-47
DOI: 10.1038/nnano.2013.230
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us