Suberu, John O., Yamin, Peyman, Leonhard, Kai, Song, Lijiang, Chemat, Smain, Sullivan, Neil F., Barker, Guy C. and Lapkin, Alexei (2014) The effect of O-methylated flavonoids and other co-metabolites on the crystallization and purification of artemisinin. Journal of Biotechnology, Volume 171 . pp. 25-33. doi:10.1016/j.jbiotec.2013.11.024

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Abstract

Methoxylated flavonoids casticin, artemetin and retusin were identified as putative causative factors for low crystallization yields of artemisinin from extracts. Comparative profiling of biomass grown in different countries found elevated levels (∼60% higher) of artemetin in the East African biomass, which also demonstrates poor crystallization yields. The single compound and the combined doping experiments at 0, 25 and 50 μg mL−1 doping levels showed that artemetin (at 50 μg mL−1) caused a reduction in the amount of artemisinin crystallized by ca. 60%. A combination of the three flavonoids at 50 μg mL−1 almost completely inhibited crystallization, reducing the yield by 98%. Treatment of extracts by adsorbents efficiently resolves the problem of low crystallization yield.

Item Type:	Journal Article
Divisions:	Faculty of Science > Chemistry Faculty of Science > Engineering Faculty of Science > Life Sciences (2010- )
Journal or Publication Title:	Journal of Biotechnology
Publisher:	Elsevier Science BV
ISSN:	0168-1656
Official Date:	February 2014
Dates:	Date Event February 2014 Published
Volume:	Volume 171
Page Range:	pp. 25-33
DOI:	10.1016/j.jbiotec.2013.11.024
Status:	Peer Reviewed
Publication Status:	Published

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