(2012) Global network reorganization during dynamic adaptations of bacillus subtilis metabolism. Science, Volume 335 (Number 6072). pp. 1099-1103. doi:10.1126/science.1206871 ISSN 0036-8075.

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Abstract

Adaptation of cells to environmental changes requires dynamic interactions between metabolic and regulatory networks, but studies typically address only one or a few layers of regulation. For nutritional shifts between two preferred carbon sources of Bacillus subtilis, we combined statistical and model-based data analyses of dynamic transcript, protein, and metabolite abundances and promoter activities. Adaptation to malate was rapid and primarily controlled posttranscriptionally compared with the slow, mainly transcriptionally controlled adaptation to glucose that entailed nearly half of the known transcription regulation network. Interactions across multiple levels of regulation were involved in adaptive changes that could also be achieved by controlling single genes. Our analysis suggests that global trade-offs and evolutionary constraints provide incentives to favor complex control programs.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title:	Science
Publisher:	American Association for the Advancement of Science
ISSN:	0036-8075
Official Date:	2012
Dates:	Date Event 2012 Published
Volume:	Volume 335
Number:	Number 6072
Page Range:	pp. 1099-1103
DOI:	10.1126/science.1206871
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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