(2012) Condition-dependent transcriptome reveals high-level regulatory architecture in bacillus subtilis. Science, Volume 335 (Number 6072). pp. 1103-1106. doi:10.1126/science.1206848 ISSN 0036-8075.

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Abstract

Bacteria adapt to environmental stimuli by adjusting their transcriptomes in a complex manner, the full potential of which has yet to be established for any individual bacterial species. Here, we report the transcriptomes of Bacillus subtilis exposed to a wide range of environmental and nutritional conditions that the organism might encounter in nature. We comprehensively mapped transcription units (TUs) and grouped 2935 promoters into regulons controlled by various RNA polymerase sigma factors, accounting for ~66% of the observed variance in transcriptional activity. This global classification of promoters and detailed description of TUs revealed that a large proportion of the detected antisense RNAs arose from potentially spurious transcription initiation by alternative sigma factors and from imperfect control of transcription termination.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title:	Science
Publisher:	American Association for the Advancement of Science
ISSN:	0036-8075
Official Date:	2012
Dates:	Date Event 2012 Published
Volume:	Volume 335
Number:	Number 6072
Page Range:	pp. 1103-1106
DOI:	10.1126/science.1206848
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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