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Genomics and outbreak investigation : from sequence to consequence
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Robinson, Esther R., Walker, Timothy M. and Pallen, Mark J. (2013) Genomics and outbreak investigation : from sequence to consequence. Genome Medicine, 5 (4). 36. doi:10.1186/gm440
An open access version can be found in:
Official URL: http://dx.doi.org/10.1186/gm440
Abstract
Outbreaks of infection can be devastating for individuals and societies. In this review, we examine the applications of new high-throughput sequencing approaches to the identification and characterization of outbreaks, focusing on the application of whole-genome sequencing (WGS) to outbreaks of bacterial infection. We describe traditional epidemiological analysis and show how WGS can be informative at multiple steps in outbreak investigation, as evidenced by many recent studies. We conclude that high-throughput sequencing approaches can make a significant contribution to the investigation of outbreaks of bacterial infection and that the integration of WGS with epidemiological investigation, diagnostic assays and antimicrobial susceptibility testing will precipitate radical changes in clinical microbiology and infectious disease epidemiology in the near future. However, several challenges remain before WGS can be routinely used in outbreak investigation and clinical practice.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QR Microbiology | ||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Bacterial diseases -- Microbiology, Microbial genomics, Nucleotide sequence | ||||
| Journal or Publication Title: | Genome Medicine | ||||
| Publisher: | BioMed Central Ltd. | ||||
| ISSN: | 1756-994X | ||||
| Official Date: | 29 April 2013 | ||||
| Dates: |
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| Volume: | 5 | ||||
| Number: | 4 | ||||
| Article Number: | 36 | ||||
| DOI: | 10.1186/gm440 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access | ||||
| Open Access Version: |
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