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Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition
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Siegrist, M. S., Unnikrishnan, Meera, McConnell, Matthew J., Borowsky, Mark, Cheng, T.-Y., Siddiqi, N., Fortune, S. M., Moody, D. Branch and Rubin, Eric J. (2009) Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition. Proceedings of the National Academy of Sciences of the United States of America, Volume 106 (Number 44). pp. 18792-18797. doi:10.1073/pnas.0900589106 ISSN 0027-8424.
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Official URL: http://dx.doi.org/10.1073/pnas.0900589106
Abstract
The Esx secretion pathway is conserved across Gram-positive bacteria. Esx-1, the best-characterized system, is required for virulence of Mycobacterium tuberculosis, although its precise function during infection remains unclear. Esx-3, a paralogous system present in all mycobacterial species, is required for growth in vitro. Here, we demonstrate that mycobacteria lacking Esx-3 are defective in acquiring iron. To compete for the limited iron available in the host and the environment, these organisms use mycobactin, high-affinity iron-binding molecules. In the absence of Esx-3, mycobacteria synthesize mycobactin but are unable to use the bound iron and are impaired severely for growth during macrophage infection. Mycobacteria thus require a specialized secretion system for acquiring iron from siderophores.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QP Physiology Q Science > QR Microbiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Secretion, Mycobacterium tuberculosis, Siderophores, Mycobacteria -- Metabolism, Iron -- Metabolism | ||||
| Journal or Publication Title: | Proceedings of the National Academy of Sciences of the United States of America | ||||
| Publisher: | National Academy of Sciences | ||||
| ISSN: | 0027-8424 | ||||
| Official Date: | November 2009 | ||||
| Dates: |
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| Volume: | Volume 106 | ||||
| Number: | Number 44 | ||||
| Page Range: | pp. 18792-18797 | ||||
| DOI: | 10.1073/pnas.0900589106 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Burroughs Wellcome Fund (BWF), National Institutes of Health (U.S.) (NIH) | ||||
| Grant number: | R01 AI48704 and R0171155 (NIH) |
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