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Unnikrishnan, Meera, Rappuoli, Rino and Serruto, Davide (2012) Recombinant bacterial vaccines. Current Opinion in Immunology, Volume 24 (Number 3). pp. 337-342. doi:10.1016/j.coi.2012.03.013 ISSN 09527915.
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Official URL: http://dx.doi.org/10.1016/j.coi.2012.03.013
Abstract
Vaccines are currently available for many infectious diseases caused by several microbes and the prevention of disease and death by vaccination has profoundly improved public health globally. However, vaccines are not yet licensed for use against many other infectious diseases and new or improved vaccines are needed to replace suboptimal vaccines, and against newly emerging pathogens. Most of the vaccines currently licensed for human use include live attenuated and inactivated or killed microorganisms. Only a small subset is based on purified components and even fewer are recombinantly produced. Novel approaches in recombinant DNA technology, genomics and structural biology have revolutionized the way vaccine candidates are developed and will make a significant impact in the generation of safer and more effective vaccines.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QR Microbiology > QR180 Immunology | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Bacterial vaccines, Recombinant DNA | ||||
| Journal or Publication Title: | Current Opinion in Immunology | ||||
| Publisher: | Elsevier Ltd. | ||||
| ISSN: | 09527915 | ||||
| Official Date: | June 2012 | ||||
| Dates: |
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| Volume: | Volume 24 | ||||
| Number: | Number 3 | ||||
| Page Range: | pp. 337-342 | ||||
| DOI: | 10.1016/j.coi.2012.03.013 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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