Unnikrishnan, Meera, Rappuoli, Rino and Serruto, Davide (2012) Recombinant bacterial vaccines. Current Opinion in Immunology, Volume 24 (Number 3). pp. 337-342. doi:10.1016/j.coi.2012.03.013

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Abstract

Vaccines are currently available for many infectious diseases caused by several microbes and the prevention of disease and death by vaccination has profoundly improved public health globally. However, vaccines are not yet licensed for use against many other infectious diseases and new or improved vaccines are needed to replace suboptimal vaccines, and against newly emerging pathogens. Most of the vaccines currently licensed for human use include live attenuated and inactivated or killed microorganisms. Only a small subset is based on purified components and even fewer are recombinantly produced. Novel approaches in recombinant DNA technology, genomics and structural biology have revolutionized the way vaccine candidates are developed and will make a significant impact in the generation of safer and more effective vaccines.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology > QR180 Immunology
Divisions:	Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Bacterial vaccines, Recombinant DNA
Journal or Publication Title:	Current Opinion in Immunology
Publisher:	Elsevier Ltd.
ISSN:	09527915
Official Date:	June 2012
Dates:	Date Event June 2012 Published
Volume:	Volume 24
Number:	Number 3
Page Range:	pp. 337-342
DOI:	10.1016/j.coi.2012.03.013
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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