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The genetic contribution to severe post-traumatic osteoarthritis
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Valdes, Ana M., Doherty, Sally A., Muir, Kenneth, Wheeler, Margaret, Maciewicz, Rose A., Zhang, Weiya and Doherty, Michael (2013) The genetic contribution to severe post-traumatic osteoarthritis. Annals of the Rheumatic Diseases, Volume 72 (Number 10). pp. 1687-1690. doi:10.1136/annrheumdis-2012-202562 ISSN 0003-4967.
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WRAP_Muir_Ann Rheum Dis-2013-Valdes-1687-90.pdf - Published Version Available under License Creative Commons Attribution Non-commercial. Download (255Kb) | Preview |
Official URL: http://dx.doi.org/10.1136/annrheumdis-2012-202562
Abstract
Objective: to compare the combined role of genetic variants loci associated with risk of knee or hip osteoarthritis (OA) in post-traumatic (PT) and non-traumatic (NT) cases of clinically severe OA leading to total joint replacement.
Methods: A total of 1590 controls, 2168 total knee replacement (TKR) cases (33.2% PT) and 1567 total hip replacement (THR) cases (8.7% PT) from 2 UK cohorts were genotyped for 12 variants previously reported to be reproducibly associated with risk of knee or hip OA. A genetic risk score was generated and the association with PT and NT TKR and THR was assessed adjusting for covariates.
Results: For THR, each additional genetic risk variant conferred lower risk among PT cases (OR=1.07, 95% CI 0.96 to 1.19; p=0.24) than NT cases (OR 1.11, 95% CI 1.06 to 1.17; p=1.55×10−5). In contrast, for TKR, each risk variant conferred slightly higher risk among PT cases (OR 1.12, 95% CI 1.07 to 1.19; p=1.82×10−5) than among NT cases (OR 1.08, 95% CI 1.03 to 1.1; p=0.00063).
Conclusions: Based on the variants reported to date PT TKR cases have at least as high a genetic contribution as NT cases.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QH Natural history > QH426 Genetics R Medicine > RD Surgery |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Osteoarthritis, Artificial joints, Orthopedic surgery, Genetics -- Research | ||||
Journal or Publication Title: | Annals of the Rheumatic Diseases | ||||
Publisher: | BMJ Group | ||||
ISSN: | 0003-4967 | ||||
Official Date: | 26 January 2013 | ||||
Dates: |
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Volume: | Volume 72 | ||||
Number: | Number 10 | ||||
Page Range: | pp. 1687-1690 | ||||
DOI: | 10.1136/annrheumdis-2012-202562 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Date of first compliant deposit: | 26 December 2015 | ||||
Date of first compliant Open Access: | 26 December 2015 | ||||
Funder: | Seventh Framework Programme (European Commission) (FP7), AstraZeneca (Firm) | ||||
Grant number: | 200800, 277849 (FP7) |
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