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Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions

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Tang, Shangming, Copsey, Alice, Jordan, Philip W., Blitzblau, Hannah G., Newcombe, Sonya, Chan, Andrew Chi-ho, Newnham, Louise, Li, Zhaobo, Gray, Stephen, Herbert, Alex D., Arumugam, Prakash , Hochwagen, Andreas, Hunter, Neil and Hoffmann, Eva (2013) Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions. PLoS Genetics, Volume 9 (Number 12). Article number e1004071. doi:10.1371/journal.pgen.1004071

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Official URL: http://dx.doi.org/10.1371/journal.pgen.1004071

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Abstract

During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation. While meiotic functions of the cohesin and condensin complexes have been delineated, the role of the third SMC complex, Smc5/6, remains enigmatic. Here we identify specific, essential meiotic functions for the Smc5/6 complex in homologous recombination and the regulation of cohesin. We show that Smc5/6 is enriched at centromeres and cohesin-association sites where it regulates sister-chromatid cohesion and the timely removal of cohesin from chromosomal arms, respectively. Smc5/6 also localizes to recombination hotspots, where it promotes normal formation and resolution of a subset of joint-molecule intermediates. In this regard, Smc5/6 functions independently of the major crossover pathway defined by the MutLγ complex. Furthermore, we show that Smc5/6 is required for stable chromosomal localization of the XPF-family endonuclease, Mus81-Mms4Eme1. Our data suggest that the Smc5/6 complex is required for specific recombination and chromosomal processes throughout meiosis and that in its absence, attempts at cell division with unresolved joint molecules and residual cohesin lead to severe recombination-induced meiotic catastrophe

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Meiosis, Chromosomes, Morphology, Molecules
Journal or Publication Title: PLoS Genetics
Publisher: Public Library of Science
ISSN: 1553-7390
Official Date: December 2013
Dates:
DateEvent
December 2013Published
Volume: Volume 9
Number: Number 12
Page Range: Article number e1004071
DOI: 10.1371/journal.pgen.1004071
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: National Institute of Environmental Health Sciences (NIEHS), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Charles A. King Trust Postdoctoral Research Fellowship Program, Medical Research Council (Great Britain) (MRC), National Institutes of Health (U.S.) (NIH), National Institute of General Medical Sciences (U.S.) (NIGMS)
Grant number: T32 ES007058-33 (NIEHS), BB/G00353X/1 (BBSRC), GM084955 (NIH/NIGMS), R01 GM088248 (NIH)

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