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Reprint of : Uterine plasticity and reproductive fitness

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Lucas, Emma S., Salker, Madhuri S. and Brosens, Jan J. (2013) Reprint of : Uterine plasticity and reproductive fitness. Reproductive Biomedicine Online, Volume 27 (Number 6). pp. 664-672. doi:10.1016/j.rbmo.2013.10.003 ISSN 1472-6483.

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Official URL: http://dx.doi.org/10.1016/j.rbmo.2013.10.003

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Abstract

Reproduction in humans is unique in two major aspects. First, the incidence of chromosomally abnormal and developmentally compromised human preimplantation embryos is exceptionally high, and second, the uterus decidualizes spontaneously each cycle, a process also responsible for the menstrual shedding of the endometrium in the absence of pregnancy. Emerging evidence suggests that these distinctive reproductive traits are functionally linked. Thus, the decidual process enables the mother to limit investment in compromised pregnancies, while menstruation imposes a need for constant recruitment of mesenchymal stem cells to regenerate and renew the endometrium each cycle. Endometrial stem cells are immune-privileged compared with other types of adult stem cells, suggesting a role for these cells in accommodating deeply invading semi-allogenic fetal trophoblast. Thus, by coupling reproductive competence to a process of constant tissue renewal, decidualization enables the human uterus to adapt to pregnancy failure and a changing ecology.

By imposing the need for cyclic renewal of the endometrium, spontaneous decidualization followed by menstruation bestows unique functions on the human endometrium that are essential for reproductive success.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016)
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Uterus -- Adaptation, Reproductive health
Journal or Publication Title: Reproductive Biomedicine Online
Publisher: Elsevier Ltd
ISSN: 1472-6483
Official Date: 2013
Dates:
DateEvent
2013Published
Volume: Volume 27
Number: Number 6
Page Range: pp. 664-672
DOI: 10.1016/j.rbmo.2013.10.003
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Description:

Refers to : Emma S. Lucas, Madhuri S. Salker, Jan J. Brosens. Uterine plasticity and reproductive fitness
Reproductive BioMedicine Online, Volume 27, Issue 5, November 2013, Pages 506-514

Version or Related Resource: Lucas, Emma S., Salker, Madhuri S. and Brosens, Jan J.. (2013) Uterine plasticity and reproductive fitness. Reproductive Biomedicine Online, 27 (5), pp. 506-514. http://wrap.warwick.ac.uk/id/eprint/58654
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