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Janus cyclic peptide–polymer nanotubes

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Danial, Maarten, My-Nhi Tran, Carmen, Young, P. G. (Philip G.), Perrier, Sébastien and Jolliffe, Katrina A. (2013) Janus cyclic peptide–polymer nanotubes. Nature Communications, Volume 4 . Article number 2780. doi:10.1038/ncomms3780 ISSN 2041-1723.

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Official URL: http://dx.doi.org/10.1038/ncomms3780

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Abstract

Self-assembled nanotubular structures have numerous potential applications but these are limited by a lack of control over size and functionality. Controlling these features at the molecular level may allow realization of the potential of such structures. Here we report a new generation of self-assembled cyclic peptide–polymer nanotubes with dual functionality in the form of either a Janus or mixed polymeric corona. A ‘relay’ synthetic strategy is used to prepare nanotubes with a demixing or mixing polymeric corona. Nanotube structure is assessed in solution using 1H–1H nuclear Overhauser effect spectroscopy NMR, and in bulk using differential scanning calorimetry. The Janus nanotubes form artificial pores in model phospholipid bilayers. These molecules provide a viable pathway for the development of intriguing nanotubular structures with dual functionality via a demixing or a mixing polymeric corona and may provide new avenues for the creation of synthetic transmembrane protein channel mimics.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH): Nanotubes, Self-assembly (Chemistry), Peptides, Polymers
Journal or Publication Title: Nature Communications
Publisher: Nature Publishing Group
ISSN: 2041-1723
Official Date: 2013
Dates:
DateEvent
2013Published
Volume: Volume 4
Article Number: Article number 2780
DOI: 10.1038/ncomms3780
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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