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Possible role of NUCB2/nesfatin-1 in adipogenesis
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Ramanjaneya, Manjunath, Addison, Melisande and Randeva, Harpal S. (2013) Possible role of NUCB2/nesfatin-1 in adipogenesis. Current pharmaceutical design, 19 (39). pp. 6976-80. doi:10.2174/138161281939131127142959
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Official URL: http://www.eurekaselect.com/118395/article
Abstract
NUCB2 and its proteolytically cleaved product nesfatin-1 were initially identified as hypothalamic neuroproteins that inhibit food intake, via a leptin-independent pathway. Since then recent studies have found NUCB2/nesfatin-1 to be expressed both centrally, as well as in peripheral tissues. The recent implementation of novel experimental approaches has produced a large body of evidence implicating NUCB2/nesfatin-1 in a diverse range of biological functions and in the modulation of food intake, energy homeostasis and metabolism. In this review, we discuss the discovery of NUCB2 and its proteolytic product nesfatin-1, and its expression in both central and peripheral tissues. In addition we shed light on the most recent discoveries supporting the role for NUCB2/nesfatin-1 in peripheral tissues and its association with metabolic alterations. Moreover, we highlight the importance of NUCB2 and nesfatin-1 in adipose tissue, its regulation of adipogenesis and obesity-associated metabolic diseases.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QP Physiology | ||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Adipose tissues, Brown adipose tissue, Fat cells, Obesity, Nerve tissue proteins, Metabolism, Metabolism -- Disorders -- Research | ||||
| Journal or Publication Title: | Current pharmaceutical design | ||||
| Publisher: | Bentham Science Publishers Ltd. | ||||
| ISSN: | 1873-4286 | ||||
| Official Date: | 1 December 2013 | ||||
| Dates: |
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| Volume: | 19 | ||||
| Number: | 39 | ||||
| Page Range: | pp. 6976-80 | ||||
| DOI: | 10.2174/138161281939131127142959 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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