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Possible role of NUCB2/nesfatin-1 in adipogenesis

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Ramanjaneya, Manjunath, Addison, Melisande and Randeva, Harpal S. (2013) Possible role of NUCB2/nesfatin-1 in adipogenesis. Current pharmaceutical design, 19 (39). pp. 6976-80. doi:10.2174/138161281939131127142959

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Official URL: http://www.eurekaselect.com/118395/article

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Abstract

NUCB2 and its proteolytically cleaved product nesfatin-1 were initially identified as hypothalamic neuroproteins that inhibit food intake, via a leptin-independent pathway. Since then recent studies have found NUCB2/nesfatin-1 to be expressed both centrally, as well as in peripheral tissues. The recent implementation of novel experimental approaches has produced a large body of evidence implicating NUCB2/nesfatin-1 in a diverse range of biological functions and in the modulation of food intake, energy homeostasis and metabolism. In this review, we discuss the discovery of NUCB2 and its proteolytic product nesfatin-1, and its expression in both central and peripheral tissues. In addition we shed light on the most recent discoveries supporting the role for NUCB2/nesfatin-1 in peripheral tissues and its association with metabolic alterations. Moreover, we highlight the importance of NUCB2 and nesfatin-1 in adipose tissue, its regulation of adipogenesis and obesity-associated metabolic diseases.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016)
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Adipose tissues, Brown adipose tissue, Fat cells, Obesity, Nerve tissue proteins, Metabolism, Metabolism -- Disorders -- Research
Journal or Publication Title: Current pharmaceutical design
Publisher: Bentham Science Publishers Ltd.
ISSN: 1873-4286
Official Date: 1 December 2013
Dates:
DateEvent
1 December 2013Published
Volume: 19
Number: 39
Page Range: pp. 6976-80
DOI: 10.2174/138161281939131127142959
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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