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Glutathione-triggered disassembly of isothermally responsive polymer nanoparticles obtained by nanoprecipitation of hydrophilic polymers
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Phillips, Daniel J., Patterson, Joseph P., O'Reilly, Rachel K. and Gibson, Matthew I. (2014) Glutathione-triggered disassembly of isothermally responsive polymer nanoparticles obtained by nanoprecipitation of hydrophilic polymers. Polymer Chemistry, Volume 5 (Number 1). pp. 126-131. doi:10.1039/c3py00991b ISSN 1759-9954.
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WRAP_Gibson_Glutathione-Triggered Disassembly.pdf - Accepted Version Download (1050Kb) | Preview |
Official URL: http://dx.doi.org/10.1039/C3PY00991B
Abstract
The encapsulation and selective delivery of therapeutic compounds within polymeric nanoparticles offers hope for the treatment of a variety of diseases. Traditional approaches to trigger selective cargo release typically rely on polymer degradation which is not always sensitive to the biological location of a material. In this report, we prepare nanoparticles from thermoresponsive polymers with a ‘solubility release catch’ at the chain-end. This release catch is exclusively activated in the presence of intracellular glutathione, triggering an ‘isothermal’ response and promoting a change in polymer solubility. This solubility switch leads to specific and rapid nanoparticle disassembly, release of encapsulated cargo and produces completely soluble polymeric side-products.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Glutathione, Polymers, Nanoparticles -- Therapeutic use, Precipitation (Chemistry), Nanomedicine | ||||
Journal or Publication Title: | Polymer Chemistry | ||||
Publisher: | Royal Society of Chemistry | ||||
ISSN: | 1759-9954 | ||||
Official Date: | 2014 | ||||
Dates: |
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Volume: | Volume 5 | ||||
Number: | Number 1 | ||||
Page Range: | pp. 126-131 | ||||
DOI: | 10.1039/c3py00991b | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Date of first compliant deposit: | 26 December 2015 | ||||
Date of first compliant Open Access: | 26 December 2015 | ||||
Funder: | European Regional Development Fund (ERDF), Higher Education Funding Council for England (HEFCE), University of Warwick |
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