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C-Peptide as a therapeutic tool in diabetic nephropathy
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Hills, Claire E., Brunskill, Nigel J. and Squires, Paul E. (2010) C-Peptide as a therapeutic tool in diabetic nephropathy. American Journal of Nephrology, Vol.31 (No.5). pp. 389-397. ISSN 0250-8095
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Official URL: http://dx.doi.org/10.1159/000289864
Abstract
Background/Aims: Insulin is synthesised as a pro-hormone with an interconnecting C-peptide, cleaved during post-translational modification. This review discusses growing evidence which indicates that C-peptide is biologically active, benefiting microvascular complications associated with diabetes. Methods: To explore the renoprotective role of C-peptide in diabetic nephropathy (DN), we reviewed the literature using PubMed for English language articles that contained key words related to C-peptide, kidney and DN. Results: Numerous studies have demonstrated that C-peptide ameliorates a number of the structural and functional renal disturbances associated with uncontrolled hyperglycaemia in human and animal models of type 1 diabetes mellitus that lead to the development and progression of nephropathy, including abrogation of glomerular hyperfiltration, reduced microalbuminuria, decreased mesangial expansion and increased endothelial nitric oxide synthase levels. The in vitro exposure of kidney proximal tubular cells to physiological concentrations of C-peptide activates extracellular signal-regulated kinase, phosphatidylinositol 3-kinase, protein kinase C, elevates intracellular calcium, and stimulates tran scription factors NF-kappa B and peroxisome proliferator-activated receptor-gamma. Conclusion: Burgeoning studies suggest that C-peptide is more than merely a link between the A and B chains of the proinsulin molecule and represents a future therapeutic tool in reducing complications of DN. Copyright (C) 2010 S. Karger AG, Basel
| Item Type: | Journal Item |
|---|---|
| Subjects: | R Medicine > RC Internal medicine |
| Divisions: | Faculty of Science > Life Sciences (2010- ) |
| Journal or Publication Title: | American Journal of Nephrology |
| Publisher: | Karger |
| ISSN: | 0250-8095 |
| Date: | 2010 |
| Volume: | Vol.31 |
| Number: | No.5 |
| Number of Pages: | 9 |
| Page Range: | pp. 389-397 |
| Identification Number: | 10.1159/000289864 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | Diabetes Research and Wellness Foundation (DRWF), Wellcome Trust |
| URI: | http://wrap.warwick.ac.uk/id/eprint/5875 |
Data sourced from Thomson Reuters' Web of Knowledge
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