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Pharmacological manipulations of interval timing using the peak procedure in male C3H mice
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Balci, Fuat, Ludvig, Elliot Andrew, Gibson, Jacqueline M., Allen, Brian D., Frank, Krystal M. , Kapustinski, Bryan J., Fedolak, Thomas E. and Brunner, Daniela (2008) Pharmacological manipulations of interval timing using the peak procedure in male C3H mice. Psychopharmacology, Volume 201 (Number 1). pp. 67-80. doi:10.1093/humrep/deh318 ISSN 0033-3158.
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Official URL: http://dx.doi.org/10.1007/s00213-008-1248-y
Abstract
Rationale:
Timing deficits are characteristic of developmental and neurodegenerative disorders that are accompanied by cognitive impairment. A prominent theory of this interval timing posits an internal clock whose pace is modulated by the neurotransmitter dopamine.
Objectives:
We tested two hypotheses about the pharmacology of interval timing in mice: (1) that general cognitive enhancers should increase, and cognitive disruptors should decrease temporal precision and (2) that acutely elevated dopamine should speed this internal clock and produce overestimation of elapsing time.
Materials and methods:
C3H mice were tested in the peak procedure, a timing task, following acute administration of two putative cognitive enhancers (atomoxetine and physostigmine), two cognitive disruptors (scopolamine and chlordiazepoxide [CDP]), or two dopamine agonists (d-amphetamine and methamphetamine).
Results
The first hypothesis received strong support: temporal precision worsened with both cognitive disruptors, but improved with both cognitive enhancers. The two dopamine agonists also produced underestimation of elapsing time—congruent with the slowing of an internal clock and inconsistent with a dopamine-driven clock.
Conclusion:
Our results suggest that interval timing has potential as an assay for generalized cognitive performance and that the dopamine-clock hypothesis needs further refinement.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Psychology | ||||
| Library of Congress Subject Headings (LCSH): | Time perception in animals, Perceptual-motor processes, Mice -- Psychology, Mice -- Effect of drugs on, Cognition -- Effect of drugs on, Nootropic agents -- Physiological effect | ||||
| Journal or Publication Title: | Psychopharmacology | ||||
| Publisher: | Springer | ||||
| ISSN: | 0033-3158 | ||||
| Official Date: | November 2008 | ||||
| Dates: |
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| Volume: | Volume 201 | ||||
| Number: | Number 1 | ||||
| Page Range: | pp. 67-80 | ||||
| DOI: | 10.1093/humrep/deh318 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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