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Food-dependent exercise-induced anaphylaxis : is wheat unique?
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Wong, Gabriel K. and Krishna, Mamidipudi (2013) Food-dependent exercise-induced anaphylaxis : is wheat unique? Current Allergy and Asthma Reports, Volume 13 (Number 6). pp. 639-644. doi:10.1007/s11882-013-0388-2
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Official URL: http://dx.doi.org/10.1007/s11882-013-0388-2
Abstract
This review draws comparisons between wheat-dependent exercise-induced anaphylaxis (WDEIA) and other food-dependent exercise-induced anaphylaxis (FDEIAs) and discusses the importance of co-factors in its pathophysiology. FDEIA remains an enigmatic condition since it was first described 30 years ago. The sporadic and unpredictable nature of its reactions has puzzled clinicians and scientists for decades, but recent studies on WDEIA have enlightened us about the pathophysiology of this condition. The identification of defined allergic epitopes such as Tri a 19, α-gliadin, β-gliadin and γ-gliadin in WDEIA enables it to become the perfect model for studying FDEIA, but WDEIA is by no means a unique condition. On a larger scale, FDEIA represents a crucial link between IgE-mediated and anaphylactoid reactions and provides supportive evidence for the concept of ‘summation anaphylaxis’ and the need to overcome the ‘allergen threshold’. Future work should focus on identifying more of the FDEIA epitopes and understanding their distinct molecular properties. The development of a biomarker in order to identify patients susceptible to co-factor influences would be invaluable.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Anaphylaxis, Wheat, Food allergy, Exercise -- Physiological aspects | ||||
| Journal or Publication Title: | Current Allergy and Asthma Reports | ||||
| Publisher: | Springer Healthcare | ||||
| ISSN: | 1529-7322 | ||||
| Official Date: | 2013 | ||||
| Dates: |
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| Volume: | Volume 13 | ||||
| Number: | Number 6 | ||||
| Page Range: | pp. 639-644 | ||||
| DOI: | 10.1007/s11882-013-0388-2 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | ALK Abello, Allergy Therapeutics, Meda Pharmaceuticals Ltd., Phadia, Nova biomedical |
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