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Unexpected evolutionary proximity of eukaryotic and cyanobacterial enzymes responsible for biosynthesis of retinoic acid and its oxidation
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Millard, Andrew D., Scanlan, David J., Gallagher, Connor, Marsh, Andrew and Taylor, Paul C. (2014) Unexpected evolutionary proximity of eukaryotic and cyanobacterial enzymes responsible for biosynthesis of retinoic acid and its oxidation. Molecular BioSystems, 10 (3). pp. 380-383. doi:10.1039/c3mb70447e
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Official URL: http://dx.doi.org/10.1039/C3MB70447E
Abstract
Biosynthesis of retinoic acid from retinaldehyde (retinal) is catalysed by an aldehyde dehydrogenase (ALDH) and its oxidation by cytochrome P450 enzymes (CYPs). Herein we show by phylogenetic analysis that the ALDHs and CYPs in the retinoic acid pathway in animals are much closer in evolutionary terms to cyanobacterial orthologs than would be expected from the standard models of evolution.
Item Type: | Journal Article | ||||||||||
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Subjects: | Q Science > QR Microbiology | ||||||||||
Divisions: | Faculty of Science > Chemistry Faculty of Science > Life Sciences (2010- ) Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Tretinoin, Cyanobacteria, Prokaryotes, Cytochrome P-450 | ||||||||||
Journal or Publication Title: | Molecular BioSystems | ||||||||||
Publisher: | Royal Society of Chemistry | ||||||||||
ISSN: | 1742-206X | ||||||||||
Official Date: | 1 March 2014 | ||||||||||
Dates: |
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Volume: | 10 | ||||||||||
Number: | 3 | ||||||||||
Page Range: | pp. 380-383 | ||||||||||
DOI: | 10.1039/c3mb70447e | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||
Funder: | University of Warwick | ||||||||||
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