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Unexpected evolutionary proximity of eukaryotic and cyanobacterial enzymes responsible for biosynthesis of retinoic acid and its oxidation

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Millard, Andrew D., Scanlan, David J., Gallagher, Connor, Marsh, Andrew and Taylor, Paul C. (2014) Unexpected evolutionary proximity of eukaryotic and cyanobacterial enzymes responsible for biosynthesis of retinoic acid and its oxidation. Molecular BioSystems, 10 (3). pp. 380-383. doi:10.1039/c3mb70447e

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Official URL: http://dx.doi.org/10.1039/C3MB70447E

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Abstract

Biosynthesis of retinoic acid from retinaldehyde (retinal) is catalysed by an aldehyde dehydrogenase (ALDH) and its oxidation by cytochrome P450 enzymes (CYPs). Herein we show by phylogenetic analysis that the ALDHs and CYPs in the retinoic acid pathway in animals are much closer in evolutionary terms to cyanobacterial orthologs than would be expected from the standard models of evolution.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology
Divisions: Faculty of Science > Chemistry
Faculty of Science > Life Sciences (2010- )
Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Tretinoin, Cyanobacteria, Prokaryotes, Cytochrome P-450
Journal or Publication Title: Molecular BioSystems
Publisher: Royal Society of Chemistry
ISSN: 1742-206X
Official Date: 1 March 2014
Dates:
DateEvent
1 March 2014Published
6 January 2014Available
3 January 2013Accepted
4 October 2013Submitted
Volume: 10
Number: 3
Page Range: pp. 380-383
DOI: 10.1039/c3mb70447e
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: University of Warwick
Adapted As:

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