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Unexpected evolutionary proximity of eukaryotic and cyanobacterial enzymes responsible for biosynthesis of retinoic acid and its oxidation
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Millard, Andrew D., Scanlan, David J., Gallagher, Connor, Marsh, Andrew and Taylor, Paul C. (2014) Unexpected evolutionary proximity of eukaryotic and cyanobacterial enzymes responsible for biosynthesis of retinoic acid and its oxidation. Molecular BioSystems, 10 (3). pp. 380-383. doi:10.1039/c3mb70447e ISSN 1742-206X.
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Official URL: http://dx.doi.org/10.1039/C3MB70447E
Abstract
Biosynthesis of retinoic acid from retinaldehyde (retinal) is catalysed by an aldehyde dehydrogenase (ALDH) and its oxidation by cytochrome P450 enzymes (CYPs). Herein we show by phylogenetic analysis that the ALDHs and CYPs in the retinoic acid pathway in animals are much closer in evolutionary terms to cyanobacterial orthologs than would be expected from the standard models of evolution.
Item Type: | Journal Article | ||||||||||
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Subjects: | Q Science > QR Microbiology | ||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Tretinoin, Cyanobacteria, Prokaryotes, Cytochrome P-450 | ||||||||||
Journal or Publication Title: | Molecular BioSystems | ||||||||||
Publisher: | Royal Society of Chemistry | ||||||||||
ISSN: | 1742-206X | ||||||||||
Official Date: | 1 March 2014 | ||||||||||
Dates: |
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Volume: | 10 | ||||||||||
Number: | 3 | ||||||||||
Page Range: | pp. 380-383 | ||||||||||
DOI: | 10.1039/c3mb70447e | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||
Date of first compliant deposit: | 26 December 2015 | ||||||||||
Date of first compliant Open Access: | 26 December 2015 | ||||||||||
Funder: | University of Warwick | ||||||||||
Adapted As: |
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